Azeotropic mixture used for development and validation of Lornoxicam in bulk and its tablet dosage form by spectrophotometric method

被引：0

作者：

Prajesh Prajapati ^{[1
]}

Vipul Vaghela ^{[2
]}

Deepak Rawtani ^{[1
]}

Harshad Patel ^{[1
]}

Jasmin Kubavat ^{[1
]}

Dharmendra Baraiya ^{[2
]}

机构：

[1] Department of Pharmaceutical Analysis,Institute of Research and Development,Gujarat Forensic Sciences University,Sector-A,NrPolice bhavan

[2] ARCollege of Pharmacy and GHPatel Institute of Pharmacy

来源：

JournalofPharmaceuticalAnalysis | 2012年 / 2卷 / 04期

关键词：

Analgesic; Chlortenoxicam; Lornoxicam; Oxicam; Spectrophotometric; Azeotropic mixture;

D O I：

暂无

中图分类号：

R927.2 [药物含量测定];

学科分类号：

1007 ;

摘要：

A novel, safe, economic and sensitive method of spectrophotometric estimation has been developed using Azeoptropic mixture (water:methanol: 60:40, v/v) for the quantitative determination of Lornoxicam, a practically water-insoluble drug. Hence, Lornoxicam stock solution was prepared in Azeoptropic mixture. Lornoxicam showed maximum absorbance at 383 nm. Beer's law was obeyed in the concentration range 4-24 mg/mL with regression coefficient of 0.999. The method was validated in terms of linearity (R 2 0.999), precision (CV for intra-day and inter-day was 0.280.68 and 0.12-0.92, respectively), accuracy (98.03-100.59% w/w) and specificity. This method is simple, precise, accurate, sensitive and reproducible and can be used for the routine quality control testing of the marketed formulations.

引用

页码：306 / 309

页数：4