Ultrasound-assisted synthesis and preliminary bioactivity of novel 2H-1,2,4-thiadiazolo[2,3-a]pyrimidine derivatives containing fluorine

被引：1
|
作者：
Mao Rong Wang
机构：
来源：
Chinese Chemical Letters | 2012年 / 23卷 / 05期
关键词：
2H-1,2,4-Thiadiazolo[2,3-a]pyrimidine; Synthesis; Ultrasound; Bioactivity;
D O I：
暂无
中图分类号：
O626.41 [间（二）氮苯（嘧啶）族];
学科分类号：
070303 ; 081704 ;
摘要：
Eight novel 5,7-disubstituted-2-{5-methyl-3-(4-trifluoromethylphenyl)isoxazol-4-ylcarbonylimino}-2H-1,2,4-thiadiazolo[2,3- a]pyrimidines were synthesized by multi-step reactions in yields 68-85%.Reactions were carried out either by ultrasound irradiation or conventional method,and found it was faster and more efficient under ultrasonic irradiation.Preliminary herbicidal activities against Echinochloa crus-galli,Digitaria sanguinalis and Chenopodium serotinum were also evaluated by flat-utensil method,and the results indicated that the target compounds exhibited significant activities,some were even higher than the control herbicide.
引用
收藏
页码：561 / 564
页数：4
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