DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus

被引：12
作者：
Keisuke Matsusaka [1 ]
Sayaka Funata [1 ,2 ]
Masashi Fukayama [1 ,2 ]
Atsushi Kaneda [3 ]
机构：
[1] Department of Molecular Oncology,Graduate School of Medicine,Chiba University
[2] Department of Pathology,Graduate School of Medicine,The University of Tokyo
[3] CREST,Japan Science and Technology Agency
来源：
World Journal of Gastroenterology | 2014年 / 20卷 / 14期
关键词：
Gastric cancer; Epigenetics; DNA methylation; Epstein-Barr virus; Helicobacter pylori;
D O I：
暂无
中图分类号：
R735.2 [胃肿瘤];
学科分类号：
100214 ;
摘要：
Gastric cancer is a leading cause of cancer death worldwide,and significant effort has been focused on clarifying the pathology of gastric cancer.In particular,the development of genome-wide analysis tools has enabled the detection of genetic and epigenetic alterations in gastric cancer;for example,aberrant DNA methylation in gene promoter regions is thought to play a crucial role in gastric carcinogenesis.The etiological viewpoint is also essential for the study of gastric cancers,and two distinct pathogens,Helicobacter pylori(H.pylori)and Epstein-Barr virus(EBV),are known to participate in gastric carcinogenesis.Chronic inflammation of the gastric epithelium due to H.pylori infection induces aberrant polyclonal methylation that may lead to an increased risk of gastric cancer.In addition,EBV infection is known to cause extensive methylation,and EBV-positive gastric cancers display a high methylation epigenotype,in which aberrant methylation extends to not only Polycomb repressive complex(PRC)-target genes in embryonic stem cells but also non-PRC-target genes.Here,we review aberrant DNA methylation in gastric cancer and the association between methylation and infection with H.pylori and EBV.
引用
收藏
页码：3916 / 3926
页数：11
相关论文
共 27 条
[1]   Characterization of interleukin-1β in Helicobacter pylori-induced gastric inflammation and DNA methylation in interleukin-1 receptor type 1 knockout (IL-1R1-/-) mice [J].
Huang, Fung-Yu ;
Chan, Annie On-On ;
Lo, Regina Cheuk-Lam ;
Rashid, Asif ;
Wong, Danny Ka-Ho ;
Cho, Chi-Hin ;
Lai, Ching-Lung ;
Yuen, Man-Fung .
EUROPEAN JOURNAL OF CANCER, 2013, 49 (12) :2760-2770
[2]   Distinct DNA methylomes of newborns and centenarians [J].
Heyn, Holger ;
Li, Ning ;
Ferreira, Humberto J. ;
Moran, Sebastian ;
Pisano, David G. ;
Gomez, Antonio ;
Diez, Javier ;
Sanchez-Mut, Jose V. ;
Setien, Fernando ;
Javier Carmona, F. ;
Puca, Annibale A. ;
Sayols, Sergi ;
Pujana, Miguel A. ;
Serra-Musach, Jordi ;
Iglesias-Platas, Isabel ;
Formiga, Francesc ;
Fernandez, Agustin F. ;
Fraga, Mario F. ;
Heath, Simon C. ;
Valencia, Alfonso ;
Gut, Ivo G. ;
Wang, Jun ;
Esteller, Manel .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (26) :10522-10527
[3]   Epstein-Barr virus-associated gastric carcinoma [J].
Fukayama, Masashi ;
Ushiku, Tetsuo .
PATHOLOGY RESEARCH AND PRACTICE, 2011, 207 (09) :529-537
[4]  
Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein[J] . MasanoriHatakeyama.Cancer Science . 2010 (1)
[5]   Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication [J].
Nakajima, Takeshi ;
Enomoto, Shotaro ;
Yamashita, Satoshi ;
Ando, Takayuki ;
Nakanishi, Yukihiro ;
Nakazawa, Kazuyuki ;
Oda, Ichiro ;
Gotoda, Takuji ;
Ushijima, Toshikazu .
JOURNAL OF GASTROENTEROLOGY, 2010, 45 (01) :37-44
[6]   Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation [J].
Suzuki, Masato ;
Mimuro, Hitomi ;
Kiga, Kotaro ;
Fukumatsu, Makoto ;
Ishijima, Nozomi ;
Morikawa, Hanako ;
Nagai, Shigenori ;
Koyasu, Shigeo ;
Gilman, Robert H. ;
Kersulyte, Dangeruta ;
Berg, Douglas E. ;
Sasakawa, Chihiro .
CELL HOST & MICROBE, 2009, 5 (01) :23-34
[7]  
Epstein–Barr virus and gastric carcinoma: virus–host interactions leading to carcinoma[J] . RumiHino,HiroshiUozaki.Cancer Science . 2008 (9)
[8]   DNA methylation as a marker for the past and future [J].
Ushijima, T ;
Nakajima, T ;
Maekita, T .
JOURNAL OF GASTROENTEROLOGY, 2006, 41 (05) :401-407
[9]  
SPECTRUM OF EPSTEIN-BARR VIRUS–ASSOCIATED DISEASES[J] . J.L. Kutok,F. Wang.Annual Review of Pathology: Mechanisms of Disease . 2006
[10]  
Hypomethylation: One Side of a Larger Picture[J] . BARBARA K.DUNN.Annals of the New York Academy of Sciences . 2006 (1)
123