抗肿瘤靶点PARP-1及其抑制剂的研究进展

被引：7

作者：

谢怡悦

石天晨

王璐莹

徐晓伟

李阳辉

林克江

机构：

[1] 中国药科大学药学院

来源：

药学进展 | 2015年 / 39卷 / 10期

关键词：

PARP-1; 抑制剂; 肿瘤;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

聚二磷酸腺苷核糖聚合酶-1(PARP-1)参与DNA损伤修复,是近年来肿瘤治疗领域的热门靶点。从PARP-1的结构和作用机制出发,综述PARP-1抑制剂的主要结构类型及优化思路,展望其应用前景和亟需解决的问题。

引用

页码：761 / 774

页数：14

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