The prognostic impact of traditional Chinese medicine monomers on tumor-associated macrophages in non-small cell lung cancer

被引：0

作者：

WAN LiangQin ^{[1
]}

TAN Yan ^{[1
]}

JIANG Miao ^{[2
]}

HUA Qian ^{[1
]}

机构：

[1] School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine

[2] Dongzhimen Hospital, Beijing University of Chinese Medicine

来源：

ChineseJournalofNaturalMedicines | 2019年 / 17卷 / 10期

关键词：

Lung cancer; Tumor microenvironment; Tumor-associated macrophages; Traditional Chinese medicine (TCM) monomer; Immunotherapy;

D O I：

暂无

中图分类号：

R285 [中药药理学];

学科分类号：

1008 ;

摘要：

Non-small cell lung cancer(NSCLC) accounts for 80%-85% of all lung malignancies and good diagnosis and prognosis of NSCLC are critical to the increase of its survival rate. Tumor-associated macrophages(TAM) abundantly present in numerous cancer types, and the role of TAMs in tumor biology and their prognostic value in cancer become major topics of interest. After various stimulations in the tumor microenvironment, TAMs develop into a M1(tumor-inhibitory) phenotype or M2(tumor-promoting) phenotype. Recent studies show that traditional Chinese medicine(TCM) monomers have markedly inhibitory actions for NSCLC through M1/M2 modulation. Due to the TCM monomers mainly covered five categories, i.e. terpenoids, flavonoids, polysaccharides, natural polyphenols, and alkaloids. Thus, we will discuss the regulation of TCM monomers on TAM involve in these five parts in this review. In addition, the potential role of TAMs as therapeutic targets will be discussed.

引用

页码：729 / 737

页数：9

共 60 条

[51]

In vitro and in vivo anti-tumor effects of Astragalus membranaceus[J] . William C.S. Cho,Kwok N. Leung.Cancer Letters . 2006 (1)

[52]

THE EVOLUTION OF ISOLATED BILATERAL LUNG CONTUSION FROM BLUNT CHEST TRAUMA IN RATS: CELLULAR AND CYTOKINE RESPONSES[J] . Krishnan Raghavendran,Bruce A Davidson,James A Woytash,Jadwiga D Helinski,Cristi J Marschke,Patricia A Manderscheid,Robert H Notter,Paul R Knight.Shock . 2005 (2)

[53]

Immunomodulation and antitumor activity by a polysaccharide–protein complex from Lycium barbarum[J] . Lu Gan,Sheng Hua Zhang,Xiang Liang Yang,Hui Bi Xu.International Immunopharmacology . 2004 (4)

[54] The chemokine system in diverse forms of macrophage activation and polarization [J].

Mantovani, A ;

Sica, A ;

Sozzani, S ;

Allavena, P ;

Vecchi, A ;

Locati, M .

TRENDS IN IMMUNOLOGY, 2004, 25 (12) :677-686

[55] Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells [J].

Ikezoe, T ;

Chen, SS ;

Tong, XJ ;

Heber, D ;

Taguchi, H ;

Koeffler, HP .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2003, 23 (04) :1187-1193

[56]

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes[J] . Alberto Mantovani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica.Trends in Immunology . 2002 (11)

[57] Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression [J].

Kataki, A ;

Scheid, P ;

Piet, M ;

Marie, B ;

Martinet, N ;

Martinet, Y ;

Vignaud, JM .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2002, 140 (05) :320-328

[58]

Suppression of lipopolysaccharide-induced nuclear factor-κB activity by theaflavin-3,3′-digallate from black tea and other polyphenols through down-regulation of IκB kinase activity in macrophages[J] . Min-Hsiung Pan,Shoei-Yn Lin-Shiau,Chi-Tang Ho,Jer-Huei Lin,Jen-Kun Lin.Biochemical Pharmacology . 2000 (4)

[59]

Macrophage infiltration in human non-small-cell lung cancer: the role of CC chemokines[J] . Douglas A. Arenberg,Michael P. Keane,Bruno DiGiovine,Steven L. Kunkel,Scott R. B. Strom,Marie D. Burdick,Mark D. Iannettoni,Robert M. Strieter.Cancer Immunology, Immunotherapy . 2000 (2)

[60] Cancer chemoprevention by tea polyphenols through mitotic signal transduction blockade [J].

Lin, JK ;

Liang, YC ;

Lin-Shiau, SY .

BIOCHEMICAL PHARMACOLOGY, 1999, 58 (06) :911-915

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