乙型肝炎肝硬化患者血清IL-10和可溶性细胞间黏附分子-1水平及其对疾病预后的判断价值

被引：6

作者：

金军 ^{[1
]}

宋震宇 ^{[2
]}

刘吉祥 ^{[1
]}

机构：

[1] 四川省巴中市中心医院消化内科

[2] 成都医学院第一附属医院消化内科

来源：

实用肝脏病杂志 | 2019年 / 22卷 / 04期

关键词：

肝硬化; 乙型肝炎; 可溶性细胞间黏附分子-1; 白细胞介素-10;

D O I：

暂无

中图分类号：

R512.62 []; R575.2 [肝硬变];

学科分类号：

摘要：

目的分析比较乙型肝炎肝硬化患者血清细胞因子水平变化及其与疾病进展的关系。方法 2014年9月～2016年8月我院收治的79例乙型肝炎肝硬化患者,其中Child-Pugh A级31例,B级25例,C级23例,另选体检健康人23例作为对照,采用ELISA法检测血清IL-2、IL-6、IL-10和可溶性细胞间黏附分子-1(sICAM-1)。结果代偿期肝硬化和失代偿期肝硬化患者血清IL-10水平水平分别为(43.5±8.4) g/L和(55.8±6.1) g/L,显著低于健康人【(247.1±43.4) g/L,P<0.01】,而血清IL-2、IL-6和sICAM-1水平分别为(148.1±21.3) g/L、(43.5±8.4) g/L和(298.5±85.7) ng/mL,和(180.6±17.1) g/L、(55.8±6.1) g/L和(685.4±164.8) ng/mL,均显著高于健康人【(22.6±6.0)g/L、(6.6±1.5) g/L和(158.7±21.5) ng/mL,P<0.05】;23例Child-Pugh C级患者血清IL-10水平为(84.3±11.4) g/L,显著低于31例Child-Pugh A级或25例Child-Pugh B级【分别为(121.3±14.6) g/L和(101.4±12.6) g/L;P<0.05】,而血清IL-2、IL-6和sICAM-1水平分别为(182.7±31.4) g/L、(57.3±7.3) g/L和(665.0±135.5) ng/mL,显著高于Child-Pugh A级或Child-Pugh B级【分别为(138.4±19.6) g/L、(42.4±6.6) g/L和(398.7±103.3) ng/mL,和(157.7±22.3) g/L、(49.9±6.2) g/L和(509.6±122.9) ng/mL,P<0.05】;肝硬化患者发生自发性细菌性腹膜炎、肝性脑病或消化道出血时,血清IL-10水平会进一步降低,而血清IL-2、IL-6和sICAM-1水平则进一步升高。结论乙型肝炎肝硬化患者血清细胞因子水平会随着疾病的变化而改变,了解这些变化对指导诊疗可能有帮助。

引用

页码：549 / 552

页数：4

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