基质金属蛋白酶-9在脑卒中的两面性

被引：3

作者：

项丽娜

谢聃

张拥波

王得新

机构：

[1] 首都医科大学附属北京友谊医院神经内科

来源：

中华神经医学杂志 | 2009年 / 11期

基金：

北京市自然科学基金;

关键词：

基质金属蛋白酶-9; 脑卒中; 血脑屏障; 出血转化; 神经修复;

D O I：

暂无

中图分类号：

R686 [筋腱、韧带、滑囊疾病及损伤];

学科分类号：

1002 ; 100210 ;

摘要：

<正> 基质金属蛋白酶(matrix metalloproteinases,MMPs)是一组锌离子依赖的蛋白酶家族,是维持组织变构的重要酶类。基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)是其中重要的一类。近年研究表明MMP-9在脑卒中起着正负双向作用,仔细平衡及协调MMP-9在脑卒中的双重角色,将更有利于脑卒中的病情判断、早期诊断和卒中后的神经功能恢复。

引用

页码：1175 / 1178

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