KIM-1和NGAL对儿童紫癜性肾炎后急性肾损伤的诊断价值

被引：14
|
作者：
郑悦 [1 ]
郭金杰 [2 ]
黄晓金 [3 ]
侯玲 [1 ]
杜悦 [1 ]
机构：
[1] 中国医科大学附属盛京医院小儿肾脏风湿免疫科
[2] 辽宁省健康产业集团抚矿总医院儿科
[3] 大连医科大学附属第二医院儿科
来源：
中国医科大学学报 | 2020年 / 49卷 / 02期
关键词：
中性粒细胞明胶酶相关脂质运载蛋白; 肾损伤分子-1; 儿童; 急性肾损伤; 紫癜性肾炎;
D O I：
暂无
中图分类号：
R726.9 [小儿泌尿科学];
学科分类号：
100202 ;
摘要：
目的探讨新型标志物肾损伤分子-1 (KIM-1)和中性粒细胞明胶酶相关脂质运载蛋白(NGAL)对儿童紫癜性肾炎后急性肾损伤(A-on-HSPN)的早期诊断价值。方法选择2018年1月至2018年10月在中国医科大学附属盛京医院小儿肾脏风湿免疫科住院的紫癜性肾炎(HSPN)肾病综合征型患儿16例及A-on-HSPN患儿9例,留取血、尿和肾脏病理组织,采用ELISA方法检测血及尿KIM-1、NGAL含量,免疫组化法检测KIM-1、NGAL在患儿肾脏中的表达。结果 A-on-HSPN组患儿血、尿KIM-1、NGAL水平明显高于HSPN组(P <0.05);KIM-1、NGAL表达于肾小管上皮细胞,且A-on-HSPN组患儿肾脏组织中KIM-1、NGAL表达明显高于HSPN组(P <0.05);尿KIM-1、NGAL水平和肾小球滤过率(GFR)呈负相关,而与24 h尿蛋白定量无明显相关性。结论 KIM-1和NGAL可作为早期诊断儿童A-on-HSPN的生物标志物。
引用
收藏
页码：156 / 160
页数：5
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