SphK1/S1P信号通路在肺纤维化发生中的作用

被引：3

作者：

刘利娟

李傲

机构：

[1] 重庆理工大学药学与生物工程学院

来源：

济宁医学院学报 | 2019年 / 42卷 / 06期

关键词：

1-磷酸鞘氨醇; 1-磷酸鞘氨醇受体; 鞘氨醇激酶; 肺纤维化;

D O I：

暂无

中图分类号：

R563.9 [其他];

学科分类号：

摘要：

纤维化是一种病理过程,其以细胞外基质(extracellular matrix,ECM)的大量沉积为主要特征。纤维化发生在包括肺、肝脏、心脏和肾脏在内的各种器官中,最终导致器官结构扭曲和严重功能障碍。1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)是一种具有生物活性的溶血磷脂,发挥多种活性,包括细胞增殖、存活、分化、迁移、炎症、血管生成和内皮屏障完整性等过程。越来越多的证据表明,Sph K1/S1P信号通路在肺纤维化疾病的发生发展中起着重要作用,研究其相关作用与功能,可为治疗难治性纤维化性疾病提供新的思路和药物治疗靶点。

引用

页码：424 / 427

页数：4

共 11 条

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