Synthesis and biological activities of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives

被引：0

作者：

FengYun Li ^{[1
]}

XiaoFeng Guo ^{[1
]}

ZhiJin Fan ^{[1
]}

YuQing Zhang ^{[1
]}

GuangNing Zong ^{[1
]}

XiaoLin Qian ^{[1
]}

LiuYong Ma ^{[1
]}

Lai Chen ^{[1
]}

YuJie Zhu ^{[1
]}

Kalinina Tatiana ^{[2
]}

Yury YuMorzherin ^{[2
]}

Nataliya PBelskaya ^{[2
]}

机构：

[1] State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University

[2] The Ural Federal University Named after the First President of Russia BNYeltsin

来源：

Chinese Chemical Letters | 2015年 / 26卷 / 10期

关键词：

1,3-Thiazole derivatives; Fungicidal activity; Anti-TMV activity;

D O I：

暂无

中图分类号：

O626.25 [间硫氮茂（噻唑）];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 2-amino-1,3-thiazole-4-carboxylic acid derivatives were designed and synthesized.Their structures were confirmed by melting points, IR,1H NMR,13 C NMR, and HRMS or elemental analysis. Biological activities of all title compounds including fungicidal activity and antivirus activity were evaluated systematically. Preliminary bioassays indicated that these compounds exhibited good fungicidal activity at 50 mg/m L, compounds 4b and 4i exhibited over 50% activity against six fungi tested.Most compounds showed good activity against TMV with different models in vivo at 100 mg/m L.Compounds 4c and 4e stood out with high effects against TMV in vivo in all models tested, including protective, inactivative, curative, and inductive activities. These data demonstrate a new strategy for fungi and virus control.

引用

页码：1315 / 1318

页数：4

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