Design-manufacturing chain (D-MC) is the most important link of the supply chain with the greatest possibility in cost reduction. How to strengthen the effective management of interfacial relationship between designer and manufacturer and increase the effcency of interface management concerns the effciency of the whole supply chain. In order to evaluate and improve the impacts of D-MC interfacial relationship, first we should construct the evaluation index system and then we should analyze the total cost and benefit of the interfacial relationship betterment, including the cost of member units in D-MC, the opportunity cost of cooperation partners, and the market returns resulted from the interfacial relationship improvement, which will advance the whole supply chain effciency as well as enhance the management performance of D-MC.