Synthesis and Crystal Structure of(Z)-2-Methyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one O-Prop-2-yn-1-yl Oxime Derivatives

被引：3

作者：

曹成桥

闫喜明

杨权力

罗华军

黄年玉

机构：

[1] HubeiKeyLaboratoryofNaturalProductsResearchandDevelopment,CollegeofBiologicalandPharmaceuticalSciences,ChinaThreeGorgesUniversity

来源：

结构化学 | 2014年 / 33卷 / 11期

关键词：

X-ray diffraction; crystal structure; dihydrobenzo[d]thiazol-7(4H)-one; cytotoxic activity; triazole;

D O I：

10.14102/j.cnki.0254-5861.2011-0350

中图分类号：

O626 [杂环化合物];

学科分类号：

070303 ; 081704 ;

摘要：

Compound(Z)-2-methyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one O-prop-2-yn-1-yl oxime, C11H12N2 OS, as a synthetic precursor of cytotoxic triazoles has been prepared and characterized by NMR spectra. Meanwhile, the crystal of IV was obtained and determined by X-ray single-crystal diffraction. Crystal data: monoclinic system, space group P21/c, a = 9.725(9), b = 8.068(7), c = 14.452(13)A, β = 98.68(2)°, V = 1120.9(17)A3, Z = 4, F(000) = 464, Dc = 1.305 g/cm3, μ = 0.263 mm-1, R = 0.0457 and w R = 0.1298 for 11511 independent reflections(Rint = 0.0709) and 2289 observed ones(I > 2σ(I)).

引用

页码：1683 / 1688

页数：6

共 14 条

[1]

Treatment of gastric cancer[J]. Michele Orditura,Gennaro Galizia,Vincenzo Sforza,Valentina Gambardella,Alessio Fabozzi,Maria Maddalena Laterza,Francesca Andreozzi,Jole Ventriglia,Beatrice Savastano,Andrea Mabilia,Eva Lieto,Fortunato Ciardiello,Ferdinando De Vita.World Journal of Gastroenterology. 2014(07)

[2] Personalizing therapies for gastric cancer: Molecular mechanisms and novel targeted therapies [J].

Michael Luis ;

Ana Tavares ;

Liliana S Carvalho ;

Lúcio Lara-Santos ;

António Araújo ;

Ramon Andrade de Mello .

World Journal of Gastroenterology, 2013, 19 (38) :6383-6397

[3] Synthesis and Crystal Structure of (E)-2-phenyl-6,7dihydrobenzofuran-4(5H)-one O-cyanomethyl Oxime [J].

金蕾 ;

方胡彪 ;

曹成桥 ;

黄年玉 ;

邹坤 ;

汪鋆植 .

结构化学, 2013, 32 (09) :1334-1338

[4]

Bifunctional ethyl 2-amino-4-methylthiazole-5-carboxylate derivatives: Synthesis and in vitro biological evaluation as antimicrobial and anticancer agents[J] . Sherif A.F. Rostom,Hassan M. Faidallah,Mohammed F. Radwan,Mona H. Badr.European Journal of Medicinal Chemistry . 2014

[5]

Gastric cancer ? : ESMO–ESSO–ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up[J] . Tom Waddell,Marcel Verheij,William Allum,David Cunningham,Andrés Cervantes,Dirk Arnold.Radiotherapy and Oncology . 2014 (1)

[6]

Synthesis, physicochemical characterization, cytotoxicity, antimicrobial, anti-inflammatory and psychotropic activity of new N -[1,3-(benzo)thiazol-2-yl]-ω-[3,4-dihydroisoquinolin-2(1 H )-yl]alkanamides[J] . Alla Zablotskaya,Izolda Segal,Athina Geronikaki,Tatiana Eremkina,Sergey Belyakov,Marina Petrova,Irina Shestakova,Liga Zvejniece,Vizma Nikolajeva.European Journal of Medicinal Chemistry . 2013

[7] Combining Molecular Targeted Drugs to Inhibit Both Cancer Cells and Activated Stromal Cells in Gastric Cancer [J].

Onoyama, Mieko ;

Kitadai, Yasuhiko ;

Tanaka, Yuichiro ;

Yuge, Ryo ;

Shinagawa, Kei ;

Tanaka, Shinji ;

Yasui, Wataru ;

Chayama, Kazuaki .

NEOPLASIA, 2013, 15 (12) :1391-1399

[8]

Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1- b]thiazoles[J] . Aldo Andreani,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi,Rinaldo Cervellati,Emanuela Greco,Tamara P. Kondratyuk,Eun-Jung Park,Ke Huang,Richard B. van Breemen,John M. Pezzuto.European Journal of Medicinal Chemistry . 2013

[9]

The H + /K + -ATPase inhibitory activities of Trametenolic acid B from Trametes lactinea (Berk.) Pat, and its effects on gastric cancer cells[J] . Qiaoyin Zhang,Nianyu Huang,Junzhi Wang,Huajun Luo,Haibo He,Mingruo Ding,Wei-Qiao Deng,Kun Zou.Fitoterapia . 2013

[10]

Molecular Design and Synthesis of HCV Inhibitors Based on Thiazolone Scaffold[J] . Ghada. H. Al-Ansary,Mohamed. A.H. Ismail,Dalal. A. Abou El Ella,Sameh Eid,Khaled. A.M. Abouzid.European Journal of Medicinal Chemistry . 2013

← 1 2 →