Effect of Long Protocol on the Outcome of In Vitro Fertilization-embryo Transfer in Patients with Endometriosis Compared with Prolonged Protocol

被引：5

作者：

Jian-ping ZHANG ^{[1
]}

Xue-qing WU ^{[1
]}

Xing-yu BI ^{[1
]}

Bing-bing CHEN ^{[1
]}

Si-ping ZHANG ^{[1
]}

Hui-ping LIU ^{[1
]}

机构：

[1] Human Assisted Reproduction Center, Shanxi Women & Children’s Hospital

来源：

Journal of Reproduction and Contraception | 2014年 / 02期

关键词：

endometriosis(EMs); down-regulation protocol; controlled ovarian hyperstimulation(COH); IVF-ET; pregnancy rate;

D O I：

暂无

中图分类号：

R714.8 [];

学科分类号：

100211 ;

摘要：

Objective To investigate the effect of different down-regulation protocol on the in vitro fertilization-embryo transfer(IVF-ET) outcomes in infertile patients with endometriosis(EMs).Methods A retrospective case control study was performed. Totally 294 infertile patients with EMs were enrolled. And 109 patients(116 cycles) received prolonged protocol as the control, 185 patients(193 cycles) received long protocol as case group, all followed by standard controlled ovarian hyperstimulation(COH). Response to gonadotropins,the fertilization rate, the cleavage rate, the implantation rate, the clinical pregnancy rate and the miscarriage rate were measured and analyzed between the two groups.Results A trend toward better ovarian response was observed in long protocol group.Higher fertilization rate, lower total dose of rFSH, shorter duration of stimulation and more endometrial thickness on the day of hCG injection were observed in long protocol group compared with those of prolonged protocol group, and the difference was significant(P<0.05). In addition, the clinical pregnancy rate, the cleavage rate and the implantation rate also had an increase trend in long protocol group compared with those of prolonged protocol group, but without significant differences.Conclusion Long protocol regimen before IVF-ET in patients with EMs resulted in a trend toward better ovarian response and higher clinical pregnancy rates than prolonged protocol regimen did.

引用

页码：81 / 88

页数：8

共 19 条

[1]

Subfertility associated with minimal to mild endometriosis. Main mechanisms. Panidis D K,Matalliotakis I M. The Journal of reproductive medicine . 1999

[2]

Hormonal profiles and embryo quality in women with severe endometriosis treated by in vitro fertilization and embryo transfer. Yovich J L,Matson P L,Richardson P A,Hilliard C. Fertility and Sterility . 1988

[3]

Laparoscopic surgery in infertile women with minimal or mild endometriosis. Canadian Collaborative Group on Endometriosis. Marcoux S,Maheux R,Bérubé S. The New England Quarterly . 1997

[4]

A comparison between a standard and reduced dose of d-Trp-6-luteinizing hormone releasing hormone administered after pituitary suppression for in vitro fertilization. Simon A,Benshushan A,Shushan A,et al. Human Reproduction . 1994

[5]

Endometrial quality in infertile women with endometriosis. Pellicer A,Navarro J,Bosch E,et al. Fertility and Sterility . 2005

[6]

ABC of subfertility: Unexplained infertility, endometriosis, and fibroids. Roger Hart. British Medical Journal . 2003

[7]

Specific gonadotro-pin-releasing hormone analogue binding predominantly in human luteinized follicular aspirates and not in human pre-ovulatory follicles. Brus L,Lambalk CB,de Koning J,et al. Human Reproduction . 1997

[8]

[Ovarian endometriomas: Effect of laparoscopic cystectomy on ovarian response in IVF-ET cycles]. Yazbeck C,Madelenat P,Sifer C,Hazout A,Poncelet C. Gynécologie, obstétrique & fertilité . 2006

[9]

Endometriotic disease: the role of peritoneal fluid. Koninckx P R,Kennedy S H,Barlow D H. Human Reproduction . 1998

[10]

Human embryos with unevenly sized blastomeres have lower pregnancy and implantation rates: indications for aneuploidy and multinucleation. Thorir Hardarson,Charles Hanson,Anita Sj?gren,Kersti Lundin. Human Reproduction . 2001

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