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Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine
被引：0
作者：
Gang Yao Yuhong Man Xiangdan Luo Tingmin Yu Lin Ji Department of Neurology Second Hospital of Jilin University Changchun Jilin Province China Department of Neurology First Hospital of Jilin University Changchun Jilin Province China Department of Food Science College of Quartermaster Technology Jilin University Changchun Jilin Province China Liaoyuan Vocational Technical and Medical College Liaoyuan Jilin Province China
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]
机构：
关键词：
proenkephalin;
substance P;
migraine;
rizatriptan benzoate;
midbrain;
real-time quantitative polymerase chain reaction;
pain;
D O I：
暂无
中图分类号：
R747.2 [偏头痛];
学科分类号：
1002 ;
摘要：
The present study utilized a nitroglycerin-induced rat model of migraine to detect the effects of rizatriptan benzoate on proenkephalin and substance P gene expression in the midbrain using real-time quantitative polymerase chain reaction and investigate whether rizatriptan benzoate can regulate the endogenous pain modulatory system. The results showed that rizatriptan benzoate significantly reduced expression of the mRNAs for proenkephalin and substance P. Rizatriptan benzoate may inhibit the analgesic effect of the endogenous pain modulatory system.
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页码：131 / 135
页数：5
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