Fast Electrical Detection of Carcinoembryonic Antigen Based on AlGaN/GaN High Electron Mobility Transistor Aptasensor

被引：0

作者：

占香蜜 ^{[1
]}

王权 ^{[1
]}

王琨 ^{[1
]}

李巍 ^{[1
]}

肖红领 ^{[1
,2
,3
]}

冯春 ^{[1
,3
]}

姜丽娟 ^{[1
,3
]}

王翠梅 ^{[1
,2
,3
]}

王晓亮 ^{[1
,2
,3
]}

王占国 ^{[1
,3
]}

机构：

[1] Key Lab of Semiconductor Materials Science,Institute of Semiconductors,Chinese Academy of Sciences

[2] School of Microelectronics,University of Chinese Academy of Sciences

[3] Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices

来源：

Chinese Physics Letters | 2017年 / 09期

基金：

中国国家自然科学基金;

关键词：

CEA; GaN; Fast Electrical Detection of Carcinoembryonic Antigen Based on AlGaN/GaN High Electron Mobility Transistor Aptasensor;

D O I：

暂无

中图分类号：

R730.4 [肿瘤诊断学]; TN386 [场效应器件];

学科分类号：

0805 ; 080501 ; 080502 ; 080903 ; 100214 ;

摘要：

As one of the most important tumor-associated antigens of colorectal adenocarcinoma, the carcinoembryonic antigen（CEA） threatens human health seriously all over the globe. Fast electrical and highly sensitive detection of the CEA with AlGaN/GaN high electron mobility transistor is demonstrated experimentally. To achieve a low detection limit, the Au-gated sensing area of the sensor is functionalized with a CEA aptamer instead of the corresponding antibody. The proposed aptasensor has successfully detected different concentrations(ranging from 50 picogram/milliliter（pg/ml） to 50 nanogram/milliliter（ng/ml）) of CEA and achieved a detection limit as low as 50 pg/ml at V;= 0.5 V. The drain-source current shows a clear increase of 11.5μA under this bias.

引用

页码：93 / 96

页数：4