EFFECTS OF MODERATE NOISE EXPOSURE ON HEARING FUNCTION IN C57BL/6J MICE

被引：2
作者：
SHI Chuang [1 ,2 ]
SHI Lei [1 ]
JIANG Xuejun [1 ]
YANG Shiming [3 ]
LIU Ke [1 ,3 ]
机构：
[1] Department of Otolaryngology Head and Neck Surgery,The First Affiliated Hospital of China Medical University
[2] Department of Otolaryngology Head and Neck surgery,Shiyan Taihe Hospital
[3] Department of Otolaryngology Head and Neck surgery,Institute of Otolaryngology,Chinese PLA General Hospital
来源：
JournalofOtology | 2014年 / 9卷 / 02期
基金：
北京市自然科学基金; 中国博士后科学基金; 中国国家自然科学基金;
关键词：
C57BL/6J mice; Noise exposure; Hearing loss; Temporary noise-induced hearing loss; ABR threshold shift;
D O I：
10.13489/j.cnki.11-4883/r.2014.02.015
中图分类号：
R764 [耳科学、耳疾病];
学科分类号：
100213 ;
摘要：
Objective To study characteristics of hearing loss after exposure to moderate noise exposure in C57BL/6J mice.Methods Male C57BL/6J mice with normal hearing at age of 5-6 weeks were chosen for this study.The mice were randomly selected to be studied immediately after exposure(Group P0),or 1 day(Group P1),3 days(Group P3),7 days(Group P7)or 14 days(P14)after exposure.Their before exposure condition served as the normal control.All mice were exposed to a broad-band white noise at 100 dB SPL for 2 hours,ABR thresholds were used to estimate hearing status at each time point.Results ABR threshold elevation was seen at every tested frequency at P0(P<0.01).Elevation at high-frequencies(16 kHz and 32 kHz)was greater than at lower frequencies(4 kHz and 8 kHz,P<0.05).From P1 to P14,ABR thresholds continuously improved,and there was no significant difference between P14 and before exposure(P>0.05).Conclusion There is a frequency specific response to 100 dB SPL broad-band white noise in C57BL/6J mice,with the high-frequency being more susceptible.Hearing loss induced by moderate noise exposure appears reversible in C57BL/6J mice.
引用
收藏
页码：81 / 85
页数：5
相关论文
共 15 条
  • [1] Dynamic distribution of ototoxic gentamicin entry into inner hair cells of mice
    Liu, Ke
    Shi, Chuang
    Sun, Yuhan
    Xu, Yice
    Shi, Lei
    Shi, Lin
    Wang, Xiaoyu
    Ji, Fei
    Hou, Zhaohui
    Yang, Shiming
    [J]. ACTA OTO-LARYNGOLOGICA, 2014, 134 (04) : 345 - 351
  • [2] Cochlear Inner Hair Cell Ribbon Synapse is the Primary Target of Ototoxic Aminoglycoside Stimuli
    Liu, Ke
    Jiang, Xuejun
    Shi, Chuang
    Shi, Lei
    Yang, Bo
    Shi, Lin
    Xu, Yice
    Yang, Weiyan
    Yang, Shiming
    [J]. MOLECULAR NEUROBIOLOGY, 2013, 48 (03) : 647 - 654
  • [3] Comparison of functional and morphologic characteristics of mice models of noise-induced hearing loss[J] . Shi-Nae Park,Sang-A. Back,Kyoung-Ho Park,Jae-Hyun Seo,He-Il Noh,Omar Akil,Laurence R. Lustig,Sang Won Yeo.Auris Nasus Larynx . 2012
  • [4] The quantitative relationship between road traffic noise and hypertension: a meta-analysis[J] . Elise van Kempen,Wolfgang Babisch.Journal of Hypertension . 2012 (6)
  • [5] Effects of Repeated “Benign” Noise Exposures in Young CBA Mice: Shedding Light on Age-related Hearing Loss[J] . Yong Wang,Chongyu Ren.Journal of the Association for Research in Otolaryngology . 2012 (4)
  • [6] Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice[J] . Kelly L. Kane,Chantal M. Longo-Guess,Leona H. Gagnon,Dalian Ding,Richard J. Salvi,Kenneth R. Johnson.Hearing Research . 2011 (1-2)
  • [7] Moderate noise induced cognition impairment of mice and its underlying mechanisms
    Cheng, Liang
    Wang, Shao-Hui
    Chen, Qi-Cai
    Liao, Xiao-Mei
    [J]. PHYSIOLOGY & BEHAVIOR, 2011, 104 (05) : 981 - 988
  • [8] Noise-induced hearing loss in Asia[J] . Adrian Fuente,Louise Hickson.International Journal of Audiology . 2011 (S1)
  • [9] Environmental noise, sleep and health[J] . Alain Muzet.Sleep Medicine Reviews . 2007 (2)
  • [10] N -Acetyl l -cysteine does not protect against premature age-related hearing loss in C57BL/6J mice: A pilot study[J] . Rickie R. Davis,Ming-Wen Kuo,Susan G. Stanton,Barbara Canlon,Edward Krieg,Kumar N. Alagramam.Hearing Research . 2006 (1)
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