Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China

被引：0

作者：

LI Xiu Ting ^{[1
]}

YU Peng Fei ^{[2
]}

GAO Yan ^{[3
]}

GUO Wen Hui ^{[4
]}

WANG Jun ^{[2
]}

LIU Xin ^{[5
]}

GU Ai Hua ^{[4
]}

JI Gui Xiang ^{[6
]}

DONG Qiu ^{[1
]}

WANG Bo Shen ^{[5
]}

CAO Ying ^{[7
]}

ZHU Bao Li ^{[2
]}

XIAO Hang ^{[2
]}

机构：

[1] Nanjing Prevention and Treatment Genter for Occupational Disease

[2] Key Lab of Modern Toxicology, Ministry of Education, Department of Toxicology, School of Public Health, Nanjing Medical University

[3] Suzhou Municipal Center for Disease Prevention and Control

[4] School of Public Health, Nanjing Medical University

[5] Jiangsu Provincial Center for Disease Control and Prevention

[6] Ministry of Environmental Protection, Nanjing Institute of Environmental Sciences

[7] Department of ENT, Huai'an Second People's Hospital

来源：

BiomedicalandEnvironmentalSciences | 2017年 / 30卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Metals; Diabetes; Chromium; Arsenic; Cadmium;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

1002 ; 100201 ;

摘要：

Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk(P < 0.05). The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed.

引用

页码：482 / 491

页数：10

共 29 条

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