产甲胎蛋白胃癌和胃肝样腺癌

被引：22

作者：

王雅坤

张小田

机构：

[1] 不详

[2] 北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所消化肿瘤内科恶性肿瘤发病机制及转化研究教育部重点实验室

[3] 不详

来源：

中华肿瘤杂志 | 2017年 / 11期

关键词：

产AFP胃癌; 胃肝样腺癌; 临床病理特征; 分子分型; 治疗; 预后;

D O I：

暂无

中图分类号：

R735.2 [胃肿瘤];

学科分类号：

摘要：

产甲胎蛋白胃癌(AFPGC)和胃肝样腺癌(HAS)是胃癌中较为特殊的2种类型,它们之间既有联系又有区别。临床上往往将AFPGC定义为血清AFP>20 ng/ml或者免疫组化AFP阳性的胃癌,HAS的诊断主要依靠病理形态学,即具有肝细胞癌分化形态特征的原发性胃癌。AFPGC和HAS的发病率均很低,尤其是HAS,为1%左右,均易发生肝转移和淋巴结转移,预后显著差于普通胃腺癌。随着高通量测序的开展,在胃癌分子分型逐渐明确的同时,人们对AFPGC和HAS的分子背景也有了一定的认识。目前,有效治疗仍是AFPGC和HAS的最大挑战,早期诊断和根治性手术切除可以很大程度地改善患者的预后,术后密切监测血清AFP水平和腹部影像学表现,有助于及早发现肝转移,而联合肝动脉介入化疗和射频消融等局部治疗可以改善患者的预后。靶向治疗在AFPGC和HAS治疗中有着广阔的前景。

引用

页码：801 / 807

页数：7

共 60 条

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