The choline pathway as a strategy to promote central nervous system(CNS) remyelination

被引：0

作者：

Thomas Skripuletz ^{[1
]}

Ralf ALinker ^{[2
]}

Martin Stangel ^{[1
,3
]}

机构：

[1] Department of Neurology, Hannover Medical School

[2] Department of Neurology, University Hospital Erlangen

[3] Center for Systems Neuroscience

来源：

NeuralRegenerationResearch | 2015年 / 10卷 / 09期

关键词：

CDP; remyelination; The choline pathway as a strategy to promote central nervous system; OPC; CNS;

D O I：

暂无

中图分类号：

R744.51 [];

学科分类号：

1002 ;

摘要：

<正>Multiple sclerosis is a chronic inflammatory disease that is accompanied by demyelination and axonal damage resulting in neurological deficits.Remyelination is the natural endogenous repair mechanism of demyelinated axons and it is supposed to protect axons/neurons from degeneration and thus the patient from progressive disability(Franklin and Ffrench-Constant,2008).Current therapeutics for patients with multiple sclerosis

引用

页码：1369 / 1370

页数：2

共 11 条

[1]

Pivotal role of choline metabolites in remyelination. Skripuletz T,Manzel A,Gropengiesser K,Schafer N,Gudi V,Singh V,Salinas\sTL,Jorg S,Hammer A,Voss E,Vulinovic F,Degen D,Wolf R,Lee DH,Pu\sR,Moharregh-Khiabani D,Baumgartner W,Gold R,Linker RA,Stangel M. Brain . 2015

[2]

Neuroprotective Properties of Citicoline: Facts, Doubts and Unresolved Issues[J] . Pawel Grieb. &nbspCNS Drugs . 2014 (3)

[3]

Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial)[J] . Antoni Dávalos,José Alvarez-Sabín,José Castillo,Exuperio Díez-Tejedor,Jose Ferro,Eduardo Martínez-Vila,Joaquín Serena,Tomás Segura,Vitor T Cruz,Jaime Masjuan,Erik Cobo,Julio J Secades. &nbspThe Lancet . 2012 (9839)

[4] Citicoline mechanisms and clinical efficacy in cerebral ischemia [J].

Adibhatla, RM ;

Hatcher, JF .

JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 70 (02) :133-139

[5] Citicoline mechanisms and clinical efficacy in cerebral ischemia [J].

Adibhatla, RM ;

Hatcher, JF .

JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 70 (02) :133-139

[6]

Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT). Zafonte Ross D,Bagiella Emilia,Ansel Beth M,Novack Thomas A,Friedewald William T,Hesdorffer Dale C,Timmons Shelly D,Jallo Jack,Eisenberg Howard,Hart Tessa,Ricker Joseph H,Diaz-Arrastia Ramon,Merchant Randall E,Temkin Nancy R,Melton Sherry,D. JAMA : the journal of the American Medical Association . 2012

[7]

Molecular insights into enzymes of membrane bilayer assembly. Russell H. Hjelmstad,Robert M. Bell. Biochemistry . 1991

[8]

De- and remyelination in the CNS white and grey matter induced by cuprizone: The old, the new, and the unexpected. Skripuletz T,Gudi V,Hackstette D,Stangel M. Histology and Histopathology . 2011

[9]

Remyelination in the CNS: from biology to therapy. Robin J. M. Franklin,Charles ffrench-Constant. Nature Reviews Neuroscience . 2008

[10]

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells. Mi Sha,Miller Robert H,Tang Wei,Lee Xinhua,Hu Bing,Wu Wutain,Zhang Yiping,Shields Christopher B,Zhang Yongjie,Miklasz Steven,Shea Diana,Mason Jeff,Franklin Robin J M,Ji Benxiu,Shao Zhaohui,Chédotal Alain,Bernard Frederic,Roulois Aude,Xu. Annals of Neurology . 2009

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