WJSC 6th Anniversary Special Issues(2):Mesenchymal stem cells Mesenchymal stem cells help pancreatic islet transplantation to control type 1 diabetes

被引：4

作者：

Marina Figliuzzi ^{[1
]}

Barbara Bonandrini ^{[1
]}

Sara Silvani ^{[1
]}

Andrea Remuzzi ^{[2
]}

机构：

[1] Department of Biomedical Engineering,IRCCS-Istituto di Ricerche Farmacologiche Mario Negri 2. Department of Industrial Engineering,University of Bergamo

来源：

World Journal of Stem Cells | 2014年 / 02期

关键词：

Mesenchymal stem cell; Islet transplantation; Type; diabetes; Vascularization; Immune modulation;

D O I：

暂无

中图分类号：

R457.7 [骨髓移植]; R587.1 [糖尿病];

学科分类号：

1002 ; 100201 ; 100215 ;

摘要：

Islet cell transplantation has therapeutic potential to treat type 1 diabetes,which is characterized by autoimmune destruction of insulin-producing pancreatic isletβcells.It represents a minimal invasive approach forβcell replacement,but long-term blood control is still largely unachievable.This phenomenon can be attributed to the lack of islet vasculature and hypoxic environment in the immediate post-transplantation period that contributes to the acute loss of islets by ischemia.Moreover,graft failures continue to occur because of immunological rejection,despite the use of potent immunosuppressive agents.Mesenchymal stem cells(MSCs)have the potential to enhance islet transplantation by suppressing inflammatory damage and immune mediated rejection.In this review we discuss the impact of MSCs on islet transplantation and focus on the potential role of MSCs in protecting islet grafts from early graft failure and from autoimmune attack.

引用

页码：163 / 172

页数：10

共 40 条

[1]

Pancreatic Islet Cell Transplantation: An Update[J] . Dimitrios T. Hatziavramidis,Theodore M. Karatzas,George P. Chrousos.Annals of Biomedical Engineering . 2013 (3)

[2]

Pathogenesis of type 1 diabetes: lessons from natural history studies of high‐risk individuals[J] . Natalie Nokoff,Marian Rewers.Annals of the New York Academy of Sciences . 2013 (1)

[3] Potential role of mesenchymal stromal cells in pancreatic islet transplantation [J].

Hematti, Peiman ;

Kim, Jaehyup ;

Stein, Andrew P. ;

Kaufman, Dixon .

TRANSPLANTATION REVIEWS, 2013, 27 (01) :21-29

[4]

Improvement in Outcomes of Clinical Islet Transplantation: 1999–2010[J] . Franca B. Barton,Michael R. Rickels,Rodolfo Alejandro,Bernhard J. Hering,Stephen Wease,Bashoo Naziruddin,Jose Oberholzer,Jon S. Odorico,Marc R. Garfinkel,Marlon Levy,Francois Pattou,Thierry Berney,Antonio Secchi,Shari Messinger,Peter A. Senior,Paola Maffi,Andrew Posselt,Peter G. Stock,Dixon B. Kaufman,Xunrong Luo,Fouad Kandeel,Enrico Cagliero,Nicole A. Turgeon,Piotr Witkowski,Ali Naji,Philip J. O’Connell,Carla Greenbaum,Yo

[5]

Islets Transplanted in Immunoisolation Devices: A Review of the Progress and the Challenges that Remain[J] . Endocrine Reviews . 2011 (6)

[6]

A genetically engineered human pancreatic[Beta] cell line exhibiting glucose-inducible insulin secretion[J] . Ravassard,Philippe,Hazhouz,Yasmine,Pechberty,Séverine,Bricout-Neveu,Emilie,Armanet,Mathieu,Czernichow,Paul,Scharfmann,Raphael.Journal of Clinical Investigation . 2011 (9)

[7] The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin [J].

Smukler, Simon R. ;

Arntfield, Margot E. ;

Razavi, Rozita ;

Bikopoulos, George ;

Karpowicz, Phillip ;

Seaberg, Raewyn ;

Dai, Feihan ;

Lee, Simon ;

Ahrens, Rosemary ;

Fraser, Paul E. ;

Wheeler, Michael B. ;

van der Kooy, Derek .

CELL STEM CELL, 2011, 8 (03) :281-293

[8] Immune modulation of co-transplantation mesenchymal stem cells with islet on T and dendritic cells [J].

Li, F. R. ;

Wang, X. G. ;

Deng, C. Y. ;

Qi, H. ;

Ren, L. L. ;

Zhou, H. X. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2010, 161 (02) :357-363

[9] Mesenchymal Stem Cell and Islet Co-Transplantation Promotes Graft Revascularization and Function [J].

Ito, Taihei ;

Itakura, Shin ;

Todorov, Ivan ;

Rawson, Jeffrey ;

Asari, Sadaki ;

Shintaku, Jonathan ;

Nair, Indu ;

Ferreri, Kevin ;

Kandeel, Fouad ;

Mullen, Yoko .

TRANSPLANTATION, 2010, 89 (12) :1438-1445

[10] Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and-9 [J].

Ding, Yunchuan ;

Xu, Danmei ;

Feng, Gang ;

Bushell, Andrew ;

Muschel, Ruth J. ;

Wood, Kathryn J. .

DIABETES, 2009, 58 (08) :1797-1806

← 1 2 3 4 →