Colorectal carcinogenesis:Road maps to cancer

被引：8

作者：

Daniel L Worthley

Vicki L Whitehall

Kevin J Spring

Barbara A Leggett

机构：

[1] Australia

[2] Conjoint Gastroenterology Laboratory The Queensland Institute of Medical Research

[3] Herston

[4] PO Royal Brisbane Hospital

[5] QLD 4029

[6] rm H07

[7] the Bancroft Centre

来源：

World Journal of Gastroenterology | 2007年 / 28期

关键词：

Colorectal cancer; Neoplastic processes; Adenoma-carcinoma sequence; Serrated adenoma; Adenomas; Hyperplastic polyps; Microsatellite instability; CpG Island methylator phenotype;

D O I：

暂无

中图分类号：

R735.3 [肠肿瘤];

学科分类号：

100214 ;

摘要：

This review explores the chief genetic and epigenetic events that promote pathological progression in colorectal carcinogenesis. This article discusses the molecular and pathological basis for classifying colorectal neoplasia into suppressor, mutator and methylator pathways. These differing mechanisms of genomic instability are associated with specific cancer characteristics, and may provide the opportunity for more effective prevention and surveillance strategies in the future. This is the first review in a series of five topics outlining important and developing aspects of colorectal cancer.

引用

页码：3784 / 3791

页数：8

共 8 条

[1]

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[2]

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[3]

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[4]

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[5]

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[6]

My approach to serrated polyps of the color-ectum. Higuchi T,Jass J R. Journal of Clinical Pathology . 2004

[7]

Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1-or APC-depleted cells. Draviam,V.M.,Shapiro,I.,Aldridge,B.,Sorger,P.K. EMBO Journal . 2006

[8]

Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Toyota M, Ho C, Ahuja N, Jair KW, Li Q, Ohe-Toyota M, Baylin SB, Issa JP. Cancer Research . 1999

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