Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy

被引：0

作者：

Nan Yang ^{[1
]}

He Liu ^{[1
]}

Yao Jiang ^{[1
]}

Ji Zheng ^{[1
]}

Dong-mei Li ^{[1
]}

Chao Ji ^{[1
]}

Yan-yong Liu ^{[1
]}

Ping-ping Zuo ^{[1
]}

机构：

[1] Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College

来源：

Neural Regeneration Research | 2015年 / 10卷 / 09期

基金：

中国国家自然科学基金;

关键词：

nerve regeneration; brain injury; hepatic encephalopathy; lactulose; neuroplasticity; neurogenesis; Morris water maze; cognition; rats; neuronal nuclei; glial fibrillary acidic protein; NSFC grants; neural regeneration;

D O I：

暂无

中图分类号：

R575.3 [肝功能衰竭];

学科分类号：

1002 ; 100201 ;

摘要：

Lactulose is known to improve cognitive function in patients with early hepatic encephalopathy; however, the underlying mechanism remains poorly understood. In the present study, we investigated the behavioral and neurochemical effects of lactulose in a rat model of early hepatic encephalopathy induced by carbon tetrachloride. Immunohistochemistry showed that lactulose treatment promoted neurogenesis and increased the number of neurons and astrocytes in the hippocampus. Moreover, lactulose-treated rats showed shorter escape latencies than model rats in the Morris water maze, indicating that lactulose improved the cognitive impairments caused by hepatic encephalopathy. The present findings suggest that lactulose effectively improves cognitive function by enhancing neuroplasticity in a rat model of early hepatic encephalopathy.

引用

页码：1457 / 1462

页数：6

共 17 条

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