Effect of Lanthanum on Acid Secretion from Isolated Mouse Stomach in Vitro

被引：0

作者：

徐项桂

夏洪涛

芮光

胡翠英

袁福根

机构：

[1] Department of Biology

[2] Department of Chemistry

[3] University of Science and Technology of Suzhou

[4] Suzhou

[5] China

来源：

JournalofRareEarths | 2004年 / 03期

关键词：

physiology; La3+ ion; isolated mouse stomach; gastric acid secretion; proglutamine; cimetidine; rare earths;

D O I：

暂无

中图分类号：

Q45 [内分泌生理学];

学科分类号：

071003 ;

摘要：

To explore the effect and the mechanism of La3+ on gastric acid secretion （GAS） of isolated mouse stomach with perfused lumen, 12 cm H2O column intragastric pressure-provided, whole stomach preparations from mice were incubated in buffer at 37 ℃ in vitro, and perfusate was measured for pH with a pHS-3 type pH meter. The results show that La3+ (0.41～820×10-6 mol·L-1) significantly promotes GAS in a concentration-dependant manner. Proglutamine, a blocker of gastrin receptor, potently inhibits GAS, and it may block the promotive effect of La3+ on GAS, and this effect increases with the increase of proglutamin concentration. Cimetidine, a blocker of histamine H2 receptor, also potently inhibits GAS, and blocks the promotive effect of La3+ on GAS in the same manner with proglutamine. These results suggest that La3+ promotes GAS in isolated stomach possibly by stimulating the releases of gastrin from G cell and Histamine from ECL cell or by activating the gastrin receptors and Histamine H2 receptors on the parietal cell, thereby accelerating the acid secretion of parietal cells in stomach.

引用

页码：427 / 430

页数：4

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