Axon degeneration: new actor in an old play

被引:0
作者
Marina Herwerth [1 ,2 ]
Matthias T.Wyss [1 ,2 ]
机构
[1] Institute of Pharmacology and Toxicology,University of Zurich
[2] Neuroscience Center Zurich,University and ETH Zurich
关键词
D O I
暂无
中图分类号
R338 [神经生理学];
学科分类号
0710 ; 071006 ;
摘要
After an insult of white matter tracts, e.g. in the spinal cord or optic nerve, axons react in general by the activation of a tightly regulated self-destruction program. This so-called axon degeneration cascade can be triggered by various causes, including injury, toxins, and genetic defects, and is a shared pathway in many different neurological diseases(Coleman and Hoke, 2020).
引用
收藏
页码:547 / 548
页数:2
相关论文
共 11 条
  • [1] A new form of axonal pathology in a spinal model of neuromyelitis optica
    Herwerth, Marina
    Kenet, Selin
    Schifferer, Martina
    Winkler, Anne
    Weber, Melanie
    Snaidero, Nicolas
    Wang, Mengzhe
    Lohrberg, Melanie
    Bennett, Jeffrey L.
    Stadelmann, Christine
    Hemmer, Bernhard
    Misgeld, Thomas
    [J]. BRAIN, 2022, 145 (05) : 1726 - 1742
  • [2] Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic strategies
    Contentti, Edgar Carnero
    Correale, Jorge
    [J]. JOURNAL OF NEUROINFLAMMATION, 2021, 18 (01)
  • [3] Small Molecule SARM1 Inhibitors Recapitulate the SARM1-/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate
    Hughes, Robert O.
    Bosanac, Todd
    Mao, Xianrong
    Engber, Thomas M.
    DiAntonio, Aaron
    Milbrandt, Jeffrey
    Devraj, Rajesh
    Krauss, Raul
    [J]. CELL REPORTS, 2021, 34 (01):
  • [4] Programmed axon degeneration: from mouse to mechanism to medicine
    Coleman, Michael P.
    Hoke, Ahmet
    [J]. NATURE REVIEWS NEUROSCIENCE, 2020, 21 (04) : 183 - 196
  • [5] PHYSIOLOGY OF ASTROGLIA
    Verkhratsky, Alexei
    Nedergaard, Maiken
    [J]. PHYSIOLOGICAL REVIEWS, 2018, 98 (01) : 239 - 389
  • [6] In Vivo Imaging Reveals Rapid Astrocyte Depletion and Axon Damage in a Model of Neuromyelitis Optica-Related Pathology
    Herwerth, Marina
    Kalluri, Sudhakar Reddy
    Srivastava, Rajneesh
    Kleele, Tatjana
    Kenet, Selin
    Illes, Zsolt
    Merkler, Doron
    Bennett, Jeffrey L.
    Misgeld, Thomas
    Hemmer, Bernhard
    [J]. ANNALS OF NEUROLOGY, 2016, 79 (05) : 794 - 805
  • [7] A recoverable state of axon injury persists for hours after spinal cord contusion in vivo
    Williams, Philip R.
    Marincu, Bogdan-Nicolae
    Sorbara, Catherine D.
    Mahler, Christoph F.
    Schumacher, Adrian-Minh
    Griesbeck, Oliver
    Kerschensteiner, Martin
    Misgeld, Thomas
    [J]. NATURE COMMUNICATIONS, 2014, 5
  • [8] dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
    Osterloh, Jeannette M.
    Yang, Jing
    Rooney, Timothy M.
    Fox, A. Nicole
    Adalbert, Robert
    Powell, Eric H.
    Sheehan, Amy E.
    Avery, Michelle A.
    Hackett, Rachel
    Logan, Mary A.
    MacDonald, Jennifer M.
    Ziegenfuss, Jennifer S.
    Milde, Stefan
    Hou, Ying-Ju
    Nathan, Carl
    Ding, Aihao
    Brown, Robert H., Jr.
    Conforti, Laura
    Coleman, Michael
    Tessier-Lavigne, Marc
    Zuechner, Stephan
    Freeman, Marc R.
    [J]. SCIENCE, 2012, 337 (6093) : 481 - 484
  • [9] A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
    Nikic, Ivana
    Merkler, Doron
    Sorbara, Catherine
    Brinkoetter, Mary
    Kreutzfeldt, Mario
    Bareyre, Florence M.
    Brueck, Wolfgang
    Bishop, Derron
    Misgeld, Thomas
    Kerschensteiner, Martin
    [J]. NATURE MEDICINE, 2011, 17 (04) : 495 - U135
  • [10] In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    Kerschensteiner, M
    Schwab, ME
    Lichtman, JW
    Misgeld, T
    [J]. NATURE MEDICINE, 2005, 11 (05) : 572 - 577