Differential diagnosis of ambiguous genitalia in Chinese patients

被引：3

作者：

田秦杰

葛秦生

机构：

[1] Division of Reproductive Endocrinology

[2] Department of Obstetrics & Gynecology

[3] Peking Union Medical College Hos-pital

[4] Chinese Academy of Medical Science

[5] Beijing

来源：

生殖医学杂志 | 2002年 / 11(S1)卷 / S1期

关键词：

Ambiguous genitalia; Androgen; Chromosome;

D O I：

暂无

中图分类号：

R691 [一般疾病]; R711.1 [女性生殖器畸形];

学科分类号：

1002 ; 100210 ; 100211 ;

摘要：

<正> Objective:To study the etiology and differential diagnosis of ambiguous genitalia.Methods:One hundred and five cases of ambiguous genitalia with disorders of sexu-al differentiation were analyzed based on clinical characteristics and basic research.Results:Ambiguous genitalia are closely related to the function of androgen.Itcould be classified into 3 groups:androgen excess,androgen deficiency and failure ofgonadal differentiation.Differential diagnosis depends on clinical manifestations,chro-mosome examination,serum hormone determinations,final gonadal pathology,receptorstudy etc.Conclusion:Ambiguous genitalia are related to abnormal androgenic effect and ear-ly correct etiological diagnosis is the key to its management.

引用

页码：38 / 41

页数：4

共 4 条

[1]

Molecular genetics of congenital adrenal hyperplasia. White PC,New MI. Bailliere s Clinical Oncology . 1988

[2]

Analysis of mutationsin the androgen receptor gene in complete androgen in-sensitivity syndrome. Tian QJ,Huang SZ,Yu Q,et al. J Reprod Med (Chinese) . 1995

[3]

SRY recognizes conserved DNA sites in sex-specific promoters. Haqq CM,King C-Y,Donahoe PK,et al. Proceedings of the National Academy of Sciences of the United States of America . 1993

[4]

Evaluation of infant who has ambiguous genitalia, and principle of operative management. Donahoe PK,Schnitzer JJ. Seminars in Pediatric Surgery . 1996

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