HBV不同感染状态者血清IL-21、IFN-γ水平变化及其临床意义

被引：9

作者：

王驭风

钱卫

夏澍

机构：

[1] 盐城市第三人民医院

来源：

山东医药 | 2017年 / 57卷 / 04期

关键词：

乙型肝炎病毒感染; 白介素21; γ干扰素; 发病机制;

D O I：

暂无

中图分类号：

R512.62 [];

学科分类号：

摘要：

目的探讨不同HBV感染状态者血清IL-21、IFN-γ水平变化及其临床意义。方法选择HBV感染者74例,根据感染状态分为急性乙肝组15例、慢性HBV携带组17例、慢性乙肝组23例、非活动性HBs Ag携带组19例,另选体检健康者20例作为对照组。采用酶联免疫吸附法检测各组血清IL-21、IFN-γ。结果急性乙肝组血清IL-21、IFN-γ水平明显高于对照组、慢性HBV携带组、慢性乙肝组和非活动性HBs Ag携带组(P均<0.05);慢性乙肝组血清IL-21水平明显高于慢性HBV携带组(P<0.05),对照组、慢性HBV携带组、慢性乙肝组和非活动性HBs Ag携带组血清IFN-γ水平组间比较均无统计学差异(P均>0.05)。对照组、急性乙肝组、慢性HBV携带组、非活动性HBs Ag携带组血清IL-21与IFN-γ水平均呈正相关(r分别为0.896、0.734、0.693、0.701,P均<0.05),慢性乙肝组血清IL-21与IFN-γ水平无相关性(r=0.359,P>0.05)。结论血清IL-21和IFN-γ水平可反映HBV感染状态,可作为判断乙肝严重程度的指标。

引用

页码：71 / 73

页数：3

共 17 条

[1] IL-12–Based Vaccination Therapy Reverses Liver-Induced Systemic Tolerance in a Mouse Model of Hepatitis B Virus Carrier[J] . Zhutian Zeng,Xiaohui Kong,Fenglei Li,Haiming Wei,Rui Sun,Zhigang Tian. &nbspThe Journal of Immunology . 2013 (8)
[2] Expression Pattern of Serum Cytokines in Hepatitis B Virus Infected Patients with Persistently Normal Alanine Aminotransferase Levels
He, Dengming
Li, Maoshi
Guo, Shimin
Zhu, Peng
Huang, Hongfei
Yan, Guohua
Wu, Quanxin
Tao, Shiqi
Tan, Zhaoxia
Wang, Yuming
[J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2013, 33 (07) : 1240 - 1249
[3] Interleukin-21 responses in patients with chronic hepatitis B. Suri H,Ren W,Ma W,et al. Journal of Interferon and Cytokine Research . 2014
[4] IL-21 restricts virusdriven Treg cell expansion in chronic LCMV infection. Schmitz I,Schneider C,Frhlich A,et al. PLoSOne . 2013
[5] Mycobacterium tuberculosis-Specific IL-21+IFN-[gamma]+CD4+T Cells Are Regulated by IL-12. Li L,Jiang Y,Lao S,et al. Plo S one . 2016
[6] IL-21R gene polymorphisms and serum\sIL-21 levels predict virological response to interferon-based therapy in\sAsian chronic hepatitis C patients. Hsu CS,Hsu SJ,Liu WL,et al. Antiviral Therapy . 2013
[7] High serum IL-21 levels after 12<ce:hsp sp="0.25"/>weeks of antiviral therapy predict HBeAg seroconversion in chronic hepatitis B[J] . Shi-Wu Ma,Xuan Huang,Yong-Yin Li,Li-Bo Tang,Xiao-Feng Sun,Xiao-Tao Jiang,Yue-Xin Zhang,Jian Sun,Zhi-Hua Liu,William G.H. Abbott,Yu-Hong Dong,Nikolai V. Naoumov,Jin-Lin Hou. &nbspJournal of Hepatology . 2011 (4)
[8] Increased Th17 cells and interleukin-17 contribute to immune activation and disease aggravation in patients with chronic hepatitis B virus infection[J] . Bo Yang,Yadong Wang,Caiyan Zhao,Wenzhao Yan,Honghao Che,Chuan Shen,Meng Zhao. &nbspImmunology Letters . 2012
[9] Interleukin 21 augments the hepatitis B virus-specific CD8+ T-cell response in vitro in patients coinfected with HIV-1
Ren, Guangxu
Esser, Stefan
Jochum, Christoph
Schlaak, Joerg F.
Gerken, Guido
Schadendorf, Dirk
Dittmer, Ulf
Wu, Gang
Yuan, Zhenghong
Timm, Joerg
[J]. AIDS, 2012, 26 (17) : 2145 - 2153
[10] 慢性HBV感染者血清IL-15和IL-16水平与HBV DNA载量的关系及临床意义探讨
李彩东
陈锡莲
李惠军
田鹏飞
吴斌
[J]. 实用肝脏病杂志, 2015, 18 (06) : 663 - 664

← 1 2 →