Synthesis and Characterization of a Novel pH-sensitive Complex for Drug Release

被引：0
作者：
许东颖 [1 ]
李光吉 [1 ]
机构：
[1] Department of Polymer Science and Engineering,South China University of Technology
来源：
Journal of Wuhan University of Technology(Materials Science) | 2010年 / 01期
基金：
中国国家自然科学基金;
关键词：
konjac glucomannan; pH-sensitivity; drug release;
D O I：
暂无
中图分类号：
R944 [剂型];
学科分类号：
100602 ; 100702 ;
摘要：
A novel pH-sensitive complex was prepared by using oxidized konjac glucomannan and 4-aminosalicylic acid (4-ASA) through glutaraldehyde as a cross-linking agent. The product was characterized by FTIR and 13C NMR spectra, and the thermogravimetric analysis was also studied. The drug release studies in vitro showed that the amount of 4-ASA released from the complex was about 4%, 56% and 17% after 12 h at pH 1.2, 6.8 and 7.4, respectively. The data demonstrate that the rate of the drug release of the complex can be more effectively controlled by pH value. The results showed that the novel pH-sensitive complex could be potentially useful for colon-targeting drug delivery system.
引用
收藏
页码：24 / 27
页数：4
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