尿肾损伤分子1和肝型脂肪酸结合蛋白水平对脓毒症急性肾损伤的预测价值

被引：14
|
作者：
高洁 [1 ]
冯阳 [1 ]
吴君俊 [1 ]
张超 [1 ]
机构：
[1] 上海市南翔医院
来源：
内科急危重症杂志 | 2020年 / 26卷 / 03期
关键词：
脓毒症; 急性肾损伤; 尿肾损伤分子1; 肝型脂肪酸结合蛋白;
D O I：
暂无
中图分类号：
R459.7 [急症、急救处理]; R692.5 [肾功能衰竭];
学科分类号：
1002 ; 100210 ; 100218 ;
摘要：
目的:探讨尿中肾损伤分子1(KIM-1)和肝型脂肪酸结合蛋白(L-FABP)水平对脓毒症急性肾损伤(AKI)的预测价值。方法:收集117例脓毒症患者的临床资料,按照是否发生AKI分为脓毒症非AKI组(76例)和脓毒症AKI组(41例)。采用ELISA法检测尿KIM-1及L-FABP水平,运用受试者工作特征(ROC)曲线及曲线下面积(AUC),评估尿KIM-1、L-FABP水平及单独或联合检测对脓毒症AKI的预测价值。结果:与脓毒症非AKI组比较,脓毒症AKI患者尿KIM-1水平在-24、0、24、48 h时间点显著升高(均P <0. 05)。脓毒症患者发生AKI前24 h,将其尿KIM-1、L-FABP水平单独或联合检测的ROC曲线进行分析,AUC分别为0. 792、0. 781和0. 818(均P <0. 05)。当取KIM-1截断值为21. 00 ng/L时,敏感性为0. 8780,特异性为0. 6447。当取L-FABP截断值为14. 00 ng/L时,敏感性为0. 7317,特异性为0. 7368。建立KIM-1联合L-FABP检测的预测模型,取截断值为0. 2239时,敏感性为0. 8780,特异性为0. 6711。结论:脓毒症发生AKI前24 h检测患者尿KIM-1及L-FABP水平,有助于预测脓毒症AKI的发生,联合检测价值较单独检测更大。
引用
收藏
页码：212 / 215
页数：4
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