Effects of Shuyusan on monoamine neurotransmitters expression in a rat model of chronic stress-induced depression

被引：0
|
作者：
Yuanyuan Zhang
机构：
来源：
NeuralRegenerationResearch | 2011年 / 6卷 / 33期
关键词：
5-hydroxytryptamine; chronic stress; depression; neurotransmitter; Shuyusan; traditional Chinese medicine;
D O I：
暂无
中图分类号：
R285.5 [中药实验药理];
学科分类号：
摘要：
Shuyusan, a traditional Chinese medicine, was shown to improve depression symptoms and behavioral scores, as well as increase 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid, and 5-hydroxytryptophan levels, in a rat model of chronic stress-induced depression. However, dopamine, noradrenalin, and 3-methoxy-4-hydroxyphenylglycol expressions remained unchanged following Shuyusan treatment. Compared with the model group, the number of 5-HT-positive neurons in layers 4-5 of the frontal cortex, as well as hippocampal CA1 and CA3 regions, significantly increased following Shuyusan treatment. These results suggested that Shuyusan improved symptoms in a rat model of chronic stress-induced depression with mechanisms that involved 5-HT, 5-HT metabolite, 5-HT precursor expressions.
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收藏
页码：2582 / 2588
页数：7
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