Retrospective Cohort Study of Preimplantation Genetic Testing for Aneuploidy with Comprehensive Chromosome Screening versus Nonpreimplantation Genetic Testing in Normal Karyotype, Secondary Infertility Patients with Recurrent Pregnancy Loss

被引：0

作者：

Lei CaiXia ^{[1
]}

Ye JiangFeng ^{[2
]}

Sui YiLun ^{[1
]}

Zhang YuePing ^{[1
]}

Sun XiaoXi

机构：

[1] Department of Genetics, Shanghai Ji Ai Genetics and IVF Institute, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China

[2] Department of Clinical Epidemiology Research, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China

来源：

生殖与发育医学（英文） | 2019年 / 3卷 / 04期

关键词：

Comprehensive Chromosome Screening; Preimplantation Genetic Testing for Aneuploidy; Recurrent Pregnancy Loss;

D O I：

暂无

中图分类号：

R714.8 [];

学科分类号：

100211 ;

摘要：

Objective: To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) with comprehensive chromosome screening increases live birth rate (LBR) in normal karyotype couples with recurrent pregnancy loss (RPL).Methods: A retrospective cohort follow-up study of 506 couples with RPL was conducted between April 2014 and March 2017. Couples were allocated to two groups according to their decision to choose PGT-A or not. The primary outcome was LBR per start/transfer cycle; secondary outcomes were ongoing pregnancy rate and miscarriage rate. Statistical analyses were conducted using univariate and multivariate logistic regression models adjusted for maternal age.Results: LBR per start (26.6% vs. 15.4%, relative risk [RR]: 2.66, 95% confidence interval [CI] [1.69-4.20],P < 0.0001; adjustedRR [aRR]: 2.40, 95%CI [1.49-3.86],P = 0.0004) and per transfer (44.9% vs. 25.1%,RR: 3.00, 95%CI [1.96-4.60],P < 0.0001; aRR: 2.64, 95%CI [1.68-4.14],P < 0.0001) was significantly higher in the PGT-A group than in the non-PGT-A group. The miscarriage rate was significantly lower in the PGT-A group compared to the non-PGT-A group (15.7% vs. 34.6%,RR: 0.27, 95%CI [0.13-0.57],P = 0.00005; aRR: 0.26, 95%CI [0.12-0.57],P = 0.0007).Conclusions: LBR per start cycle following PGT-A is significantly higher, and risk of miscarriage is significantly lower among infertile couples with RPL, irrespective of maternal age. PGT-A should be recommended to infertile couples with RPL.

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