KIF23在结直肠癌中的表达及其临床意义

被引：3
|
作者：
纪知语
密奥宁
李蒙蒙
李全营
秦长江
机构：
[1] 河南大学淮河医院普外科
来源：
中国肿瘤临床 | 2020年 / 47卷 / 07期
关键词：
结直肠癌; KIF23; 预后;
D O I：
暂无
中图分类号：
R735.34 [];
学科分类号：
摘要：
目的:探讨KIF23在结直肠癌中的表达及其临床意义。方法:分析TCGA数据库中KIF23 mRNA在结直肠癌中的表达。分析2010年2月至2013年2月于河南大学淮河医院行手术治疗的116例结直肠癌组织标本及患者临床病理资料,通过免疫组织化学法检测KIF23在结直肠癌组织中的表达,分析其与临床病理参数及预后的相关性。结果:TCGA数据库分析结果表明,癌组织中KIF23 mRNA表达水平增高(P<0.05)。免疫组织化学法检测结果提示61.2%(71/116)的结直肠癌组织中KIF23蛋白表达阳性。KIF23蛋白表达与T、N、M及TNM分期有相关性(P<0.05)。Kaplan-Meier生存分析提示与低表达KIF23相比,高表达KIF23患者的总生存时间、无复发生存时间显著缩短(P<0.05)。Cox回归分析提示KIF23是影响结直肠癌患者预后的独立危险因素。结论:KIF23在结直肠癌中高表达,可能成为预测结直肠癌患者发生发展及预后的分子标记物。
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页码：338 / 343
页数：6
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