Phage display: development of nanocarriers for targeted drug delivery to the brain

被引：1

作者：

Babak Bakhshinejad ^{[1
]}

Marzieh Karimi ^{[1
]}

Mohammad Khalaj-Kondori ^{[2
]}

机构：

[1] Department of Genetics,Faculty of Biological Sciences,Tarbiat Modares University

[2] Department of Biology,Faculty of Natural Sciences,University of Tabriz

来源：

Neural Regeneration Research | 2015年 / 10卷 / 06期

关键词：

blood brain barrier; phage display; peptide library; nanocarrier; targeting;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

1002 ;

摘要：

The blood brain barrier represents a formidable obstacle for the transport of most systematically administered neurodiagnostics and neurotherapeutics to the brain. Phage display is a high throughput screening strategy that can be used for the construction of nanomaterial peptide libraries. These libraries can be screened for finding brain targeting peptide ligands. Surface functionalization of a variety of nanocarriers with these brain homing peptides is a sophisticated way to develop nanobiotechnology-based drug delivery platforms that are able to cross the blood brain barrier. These efficient drug delivery systems raise our hopes for the diagnosis and treatment of various brain disorders in the future.

引用

页码：862 / 865

页数：4

共 11 条

[1] Bacteriophages and medical oncology: targeted gene therapy of cancer[J] . Babak Bakhshinejad,Marzieh Karimi,Majid Sadeghizadeh.Medical Oncology . 2014 (8)
[2] Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review[J] . Joana Bicker,Gilberto Alves,Ana Fortuna,Amílcar Falc?o.European Journal of Pharmaceutics and Biopharmaceutics . 2014
[3] Shaping cancer nanomedicine: the effect of particle shape on the in vivo journey of nanoparticles[J] . Randall Toy,Pubudu M Peiris,Ketan B Ghaghada,Efstathios Karathanasis.Nanomedicine . 2014 (1)
[4] Brain Delivery of NAP with PEG-PLGA Nanoparticles Modified with Phage Display Peptides
Li, Jingwei
Zhang, Chi
Li, Jing
Fan, Li
Jiang, Xinguo
Chen, Jun
Pang, Zhiqing
Zhang, Qizhi
[J]. PHARMACEUTICAL RESEARCH, 2013, 30 (07) : 1813 - 1823
[5] Novel phage display-derived neuroblastoma-targeting peptides potentiate the effect of drug nanocarriers in preclinical settings
Loi, Monica
Di Paolo, Daniela
Soster, Marco
Brignole, Chiara
Bartolini, Alice
Emionite, Laura
Sun, Jessica
Becherini, Pamela
Curnis, Flavio
Petretto, Andrea
Sani, Monica
Gori, Alessandro
Milanese, Marco
Gambini, Claudio
Longhi, Renato
Cilli, Michele
Allen, Theresa M.
Bussolino, Federico
Arap, Wadih
Pasqualini, Renata
Corti, Angelo
Ponzoni, Mirco
Marchio, Serena
Pastorino, Fabio
[J]. JOURNAL OF CONTROLLED RELEASE, 2013, 170 (02) : 233 - 241
[6] In vivo phage display — A discovery tool in molecular biomedicine[J] . Janka Bábí?ková,?ubomíra,Tóthová,Peter Boor,Peter Celec.Biotechnology Advances . 2013
[7] Assembly of Bacteriophage into Functional Materials[J] . Sung Ho Yang,Woo‐Jae Chung,Sean McFarland,Seung‐Wuk Lee.The Chemical Record . 2012 (1)
[8] Identification of peptide sequences that target to the brain using in vivo phage display
Li, Jingwei
Zhang, Qizhi
Pang, Zhiqing
Wang, Yuchen
Liu, Qingfeng
Guo, Liangran
Jiang, Xinguo
[J]. AMINO ACIDS, 2012, 42 (06) : 2373 - 2381
[9] Identification of a peptide that interacts with Nestin protein expressed in brain cancer stem cells
Beck, Samuel
Jin, Xun
Yin, Jinlong
Kim, Sung-Hak
Lee, Nam-Kyung
Oh, Se-Yeong
Jin, Xiong
Kim, Min-Kook
Kim, Eun-Bae
Son, Jee-Soo
Kim, Sung-Chan
Nam, Do-Hyun
Kim, Se-Hyuk
Kang, Sang-Kee
Kim, Hyunggee
Choi, Yun-Jaie
[J]. BIOMATERIALS, 2011, 32 (33) : 8518 - 8528
[10] Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides[J] . Jingwei Li,Liang Feng,Li Fan,Yuan Zha,Liangran Guo,Qizhi Zhang,Jun Chen,Zhiqing Pang,Yuchen Wang,Xinguo Jiang,Victor C. Yang,Longping Wen.Biomaterials . 2011 (21)

← 1 2 →