Skin Penetration of Inorganic and Metallic Nanoparticles

Nanotechnology is a rapidly growing science of producing and utilizing nano-sized particles. These nanomaterials are already having an impact on health care. Nowadays we are using nanoproducts in various fields,and this leads to direct and indirect exposure in human. Skin is the largest organ of the body and functions as the first-line barrier between the external environment and the internal organs of the human body. Then people worry about the nanoparticle(NP) small enough to penetrate the skin. The potential of solid NPs to penetrate the stratum corneum and to diffuse into underlying structures raises a considerable health and safety issue for their topical use. We review the current state of knowledge on the potential risk to human health presented by skin penetration of NPs nanotechnologies, and explore the robustness of current research strategies and directions to ensure the development of "safe" and publicly accepted nano-based products and technologies.