Research Advances on the Chemical Constituents and Pharmacological Activities of Ilex cornuta Lindl.et Paxt.

[Objective] To review the research advances on the chemical constituents and pharmacological activities of Ilex cornuta Lindl.et Paxt.,and study the future research orientation.[Method] The existing researches on the chemical consitutent and pharmacological activities of cornuta are collected and arranged.[Result] 40 compounds have been seperated from Ilex cornuta Lindl.et Paxt.,including 18 triterpenoid saponins and its aglycon,5 flavonoids and its glycoside,5 polyphenols and its derivatives,7 fatty acids and 5 others(chain sesquiterpene,tanacetene,daucosterol,cornutaside A and B).The extract had the hypolipidemic,antimicrobial and antifertility effects.Monomeric compound like ursolic acid has the sedative,anti-imflammatory,antimicrobial,antibiabetic,antiulcer and hypolipidemic efficacy,and improve the immune function,anti-carcinogeneic and anti-angiogenic effect,and induce differentiation of F9 teratoma cells;quercetin and hyperin have strong sedative and anti-cerebral ischemic injury effect,and could enhance cerebral blood flow;cornuta glycosides could protect the myocardial ischemia of rats induced by pituitrin and significantly reduce myocardial contractility;adenosine increase coronary blood flow,3,4-Dicaffeoyl-quinic acid significantly improve the release of PGI2.[Conclusion] The study could provide references for better developing and utilizing the Ilex cornuta Lindl.et Paxt.resources.