The Association between Myeloperoxidase-463G/A Gene Polymorphism and Coronary Artery Disease

被引：0

作者：

吴士礼 ^{[1
]}

李惠 ^{[1
]}

黄宇理 ^{[1
]}

王洪巨 ^{[1
]}

张恒 ^{[1
]}

包宗明 ^{[1
]}

机构：

[1] Department of cardiology, The First Affiliated Hospital of Bengbu Medical Colloge

来源：

SouthChinaJournalofCardiology | 2008年 / 03期

关键词：

myeloperoxidase; coronary artery disease; gene polymorphism;

D O I：

10.16268/j.cnki.44-1512/r.2008.03.003

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

To study the relationship between myeloperoxidase(MPO)-463G/A polymorphisms and susceptibility to coronary artery disease (CAD) in Han people of north Anhui province. Methods The case group consisted of 79 patients who had all angiographically proven CAD were retrospectively studied. Used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods to decide the genotype of all the patients. Results The frequency of AA homozygotic type in Han people of Anhui province was 1.4%. The risk of CAD for person carrying at least one A allele genotype (GA and AA) was 0.37 times of GG genotype. The severity of coronary artery stenosis in CAD patients carrying at least one A allele genotype was 0.197 times of GG genotype (P<0.05). Conclusions The frequency of AA homozygotic type and MPO-463G/A polymorphism in Han people of Anhui province influenced the risk of CAD. A allele had protective function in CAD.

引用

页码：116 / 119

页数：4

共 3 条

[1] A functional myeloperoxidase polymorphic variant is associated with coronary artery disease in French-Canadians [J].

Nikpoor, B ;

Turecki, G ;

Fournier, C ;

Théroux, P ;

Rouleau, GA .

AMERICAN HEART JOURNAL, 2001, 142 (02) :336-339

[2] Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer's disease [J].

Reynolds, WF ;

Rhees, J ;

Maciejewski, D ;

Paladino, T ;

Sieburg, H ;

Maki, RA ;

Masliah, E .

EXPERIMENTAL NEUROLOGY, 1999, 155 (01) :31-41

[3]

The myeloperoxidase product hypochlorous acid oxidizes HDL in the humanartery wall and impairs ABCA1-dependent cholesterol transport .2 Bergt C,Pennathur S,Fu X,Byun J,O’’Brien K,McDonald TO,Singh P,Anantharamaiah GM,Chait A,Brunzell J,Geary RL,Oram JF,Heinecke JW. Proc NatlAcad Sci USA . 2004

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