尿IGFBP-7对危重症患儿急性肾损伤的早期预测价值

被引：5

作者：

戴小妹 ^{[1
]}

陈娇 ^{[2
]}

陆春久 ^{[1
]}

王雪芹 ^{[1
]}

柏振江 ^{[2
]}

李艳红 ^{[3
,1
]}

机构：

[1] 苏州大学附属儿童医院肾脏科

[2] 苏州大学附属儿童医院重症医学科

[3] 苏州大学附属儿童医院儿科临床研究院

来源：

临床儿科杂志 | 2019年 / 37卷 / 04期

关键词：

急性肾损伤; 胰岛素样生长因子结合蛋白7; 儿童死亡风险评分Ⅲ; 危重症患儿;

D O I：

暂无

中图分类号：

R720.597 [儿科急症及处理]; R726.9 [小儿泌尿科学];

学科分类号：

100202 ;

摘要：

目的探讨尿胰岛素样生长因子结合蛋白7(IGFBP-7)对危重症患儿急性肾损伤(AKI)的早期预测价值。方法选择2012年5月至8月儿童重症监护病房(PICU)收治的患儿为研究对象。分为轻度AKI(AKI 1期)、严重AKI(AKI2和3期)和非AKI组。检测入PICU第一个24小时尿IGFBP-7水平,并于入PICU 24小时内行儿童死亡风险Ⅲ(PRISMⅢ)评分。以多因素logistic回归分析评估在校正混杂因素后尿IGFBP-7与AKI的关系,用受试者工作特征曲线(ROC)及曲线下面积(AUC)评价尿IGFBP-7对危重症患儿AKI的早期预测价值。结果共纳入危重症患儿144例,21例(14.6%)在样本采集120小时内发生AKI,其中严重AKI 11例。严重AKI组入PICU第一个24小时的尿IGFBP-7水平、PRISMⅢ评分均高于轻度AKI及无AKI组,差异均有统计学意义(P<0.05)。Logistic回归分析显示,在校正年龄、体质量、PRISMⅢ评分后,尿IGFBP-7是严重AKI的独立危险因素(OR=2.93,95%CI:1.07～8.03,P=0.037),预测危重症患儿严重AKI的AUC值为0. 79(95%CI:0. 66～0. 92,P=0. 001)。结论尿IGFBP-7是危重症患儿严重AKI的独立预测指标,具有早期预测价值。

引用

页码：277 / 281

页数：5

共 23 条

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