MAGE-A9在肝细胞癌中的表达及其意义

被引：0

作者：

傅茂英

倪慧慧

张伟

金凤

龚力

机构：

[1] 江苏大学附属昆山市第一人民医院感染科

来源：

肿瘤研究与临床 | 2016年 / 28卷 / 03期

关键词：

癌, 肝细胞; MAGE-A9; 聚合酶链反应; 免疫组织化学; 预后;

D O I：

暂无

中图分类号：

R735.7 [肝肿瘤];

学科分类号：

摘要：

目的探讨MAGE-A9在人类肝细胞癌中的表达及其与肝细胞癌患者临床病理特征之间的关系。方法应用反转录聚合酶链反应(RT-PCR)、实时荧光定量核酸扩增检测(qPCR)和免疫组织化学方法分析MAGE-A9在肝癌细胞株和组织标本中的表达。使用Kaplan-Meier统计方法和Cox比例风险回归模型来进行生存分析, 评估100例肝细胞癌患者的预后。结果 MAGE-A9 mRNA在肝细胞癌中的表达(4.44±0.34)明显高于非肿瘤细胞和组织(1.73±0.18)(P<0.05), MAGE-A9的表达与病理分级(P=0.003)、门静脉侵犯(P=0.001)、远处转移(P=0.022)和TNM分期(P=0.005)有关。Cox回归分析进一步表明, MAGE-A9表达是无病生存期(P=0.006)和总生存期(P=0.022)的独立预后因素。结论 MAGE-A9是与肝细胞癌患者预后相关的有价值的生物标志物, MAGE-A9高表达的肝细胞癌患者预后较差。

引用

页码：174 / 178 +182

页数：6

共 23 条

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