microRNA let-7与肿瘤

被引:0
|
作者
刘治
雷小勇
机构
[1] 湖南衡阳南华大学药物药理研究所
关键词
let-7; 肿瘤; 微小RNA;
D O I
暂无
中图分类号
R730.2 [肿瘤病理学、病因学];
学科分类号
摘要
微小RNA(miRNA)是一类长18~25个核苷酸的非编码小分子RNA,能与靶mRNA的3′UTR碱基配对,通过抑制mRNA的翻译或直接使mRNA降解,在转录后水平使基因沉默。miRNA调节的基因调控机制与肿瘤的发生、发展密切相关。Let-7是目前研究最为广泛的miRNA之一。在多种肿瘤中,let-7表达下调,提示let-7必然与肿瘤存在一些重要的联系。本文就对let-7的生物学特性、作用机制与肿瘤的关系及其在肿瘤治疗方面的潜在作用进行综述。
引用
收藏
页码:1025 / 1028
页数:4
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