肠道微生物调控宿主食欲的研究进展

被引：9
作者：
张亚南
余凯凡
朱伟云
机构：
[1] 江苏省消化道营养与动物健康重点实验室南京农业大学消化道微生物研究室
来源：
微生物学报 | 2017年 / 57卷 / 07期
关键词：
肠道微生物; 微生物代谢物; 肠-脑轴; 胃肠激素; 食欲;
D O I：
10.13343/j.cnki.wsxb.20160399
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
肠道微生物与宿主代谢相互作用,可调节机体的生理功能。宿主机体中存在"微生物-肠道-大脑轴",肠道菌群可通过多种途径影响中枢神经系统,进而对宿主摄食等行为产生影响。食物中不易被宿主消化吸收的膳食纤维等营养物质,被肠道微生物发酵可产生多种代谢产物,这些代谢产物作为信号分子可通过不同途径介导中枢神经系统,进而调控宿主食欲。本文主要综述了肠道微生物及其代谢产物对中枢神经系统与宿主食欲的影响及其可能的调控途径与机制,以加深肠道微生物在调控宿主食欲方面的新认识。
引用
收藏
页码：951 / 960
页数：10
相关论文
共 20 条
[1]  
Control of Brain Development, Function, and Behavior by the Microbiome[J] . Timothy R. Sampson,Sarkis K. Mazmanian.Cell Host & Microbe . 2015 (5)
[2]  
Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial[J] . Candida J. Rebello,Jeffrey Burton,Mark Heiman,Frank L. Greenway.Journal of Diabetes and Its Complications . 2015 (8)
[3]   Evidence supporting an altered immune response in ASD [J].
Mead, Jennifer ;
Ashwood, Paul .
IMMUNOLOGY LETTERS, 2015, 163 (01) :49-55
[4]   Intestinal glucose metabolism revisited [J].
Mithieux, Gilles ;
Gautier-Stein, Amandine .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2014, 105 (03) :295-301
[5]  
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis[J] . S.M. O’Mahony,G. Clarke,Y.E. Borre,T.G. Dinan,J.F. Cryan.Behavioural Brain Research . 2014
[6]   Specialized Metabolites from the Microbiome in Health and Disease [J].
Sharon, Gil ;
Garg, Neha ;
Debelius, Justine ;
Knight, Rob ;
Dorrestein, Pieter C. ;
Mazmanian, Sarkis K. .
CELL METABOLISM, 2014, 20 (05) :719-730
[7]   Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells [J].
Chimerel, Catalin ;
Emery, Edward ;
Summers, David K. ;
Keyser, Ulrich ;
Gribble, Fiona M. ;
Reimann, Frank .
CELL REPORTS, 2014, 9 (04) :1202-1208
[8]   γ-Aminobutyric acid production by culturable bacteria from the human intestine [J].
Barrett, E. ;
Ross, R. P. ;
O'Toole, P. W. ;
Fitzgerald, G. F. ;
Stanton, C. .
JOURNAL OF APPLIED MICROBIOLOGY, 2012, 113 (02) :411-417
[9]  
Metabolic and hedonic drives in the neural control of appetite: who is the boss?[J] . Hans-Rudolf Berthoud.Current Opinion in Neurobiology . 2011 (6)
[10]   Serotonin 2C Receptor Activates a Distinct Population of Arcuate Pro-opiomelanocortin Neurons via TRPC Channels [J].
Sohn, Jong-Woo ;
Xu, Yong ;
Jones, Juli E. ;
Wickman, Kevin ;
Williams, Kevin W. ;
Elmquist, Joel K. .
NEURON, 2011, 71 (03) :488-497
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