Computer-aided identification of protein targets of four polyphenols in Alzheimer's disease(AD)and validation in a mouse AD model

被引：0

作者：

Chaoyun Li ^{[1
]}

Ping Meng ^{[2
]}

Benzheng Zhang ^{[2
]}

Hong Kang ^{[3
]}

Hanli Wen ^{[2
]}

Hermann Schluesener ^{[1
]}

Zhiwei Cao ^{[3
]}

Zhiyuan Zhang ^{[2
]}

机构：

[1] Institute of Pathology and Neuropathology, University of Tuebingen

[2] Department of Pathology, Nanjing Medical University

[3] School of Life Sciences and Technology, Tongji University

来源：

The Journal of Biomedical Research | 2019年 / 33卷 / 02期

关键词：

Alzheimer’s disease; polyphenol; INVDOCK; cerebral amyloidosis; behavioral deficit;

D O I：

暂无

中图分类号：

R749.16 []; R-332 [医用实验动物学];

学科分类号：

1001 ; 100203 ;

摘要：

Natural polyphenols are a large class of phytochemicals with neuroprotective effects. Four polyphenolic compounds: hesperidin, icariin, dihydromyricetin and baicalin were selected to evaluate their effects on Alzheimer’s disease(AD). We analyzed by an inverse docking procedure(INVDOCK) the potential protein targets of these polyphenols within the KEGG AD pathway. Consequently, their therapeutic effects were evaluated and compared in a transgenic APP/PS1 mouse model of AD. These polyphenols were docked to several targets, including APP, BACE,PSEN, IDE, CASP, calpain and TNF-a, suggesting potential in vivo activities. Five month old transgenic mice were treated with these polyphenols. Icariin and hesperidin restored behavioral deficits and ameliorated Aβ deposits in both the cortex and hippocampus while baicalin and dihydromyricetin showed no substantial effects. Our findings suggest that hesperidin and icariin could be considered potential therapeutic candidates of human AD.

引用

页码：101 / 112

页数：12

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