The role of liver sinusoidal endothelial cells in liver remodeling after injury

被引：0
作者：
Zhi-Wen Li
Lin Wang
机构：
[1] DepartmentofHepatobiliarySurgery,XijingHospital,TheFourthMilitaryMedicalUniversity
来源：
Hepatobiliary & Pancreatic Diseases International | 2023年 / 22卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R657.3 [肝及肝管];
学科分类号：
1002 ; 100210 ;
摘要：
Liver transplantation is the optimal treatment for patients with end-stage liver disease, metabolic liver diseases, and hepatic malignancies that are not amenable to resection. Hepatic ischemia-reperfusion injury(IRI) is the main problem in liver transplantation and liver resection, leading to parenchymal cell injury and organ dysfunction. The damage of liver sinusoidal endothelial cells(LSECs) is a critical event in IRI. LSECs work as an important regulating factor of liver regeneration after partial hepatectomy. This review primarily describes the mechanisms of LSECs injury in IRI and explores the roles of LSECs in liver regeneration, and briefly introduces the protective strategies targeting LSECs damaged in IRI.
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页码：22 / 27
页数：6
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