Suppression of Growth of Hela, EJ, SK-OV-3 and MDA-MB-231 Cells by Recombinant Human NK4

Objective:To study the effects of recombinant human Nk4 on the growth and invasion activities of tumor cells. Methods:The inhibition of recombinant human NK4 on human oophoroma,cervical tumor,breast tumor and gallbladder tumor cells was evaluated in vitro by basement membrane invasion assay. Results:rhNK4 could markedly inhibited the growth of human oophoroma,cervical tumor and breast tumor cells. The inhibition rates of human oophoroma,cervical tumor,breast tumor and gallbladder tumor cells were 48.2%,29.2%,58.4% and 30.1% respectively. Conclusion:rhNK4 factor can markedly inhibit the invasion of multiple tumor cells.