Temporal changes in circulating P-selectin,plasminogen activator inhibitor-1,magnesium,and creatine kinase after percutaneous coronary intervention

Objective:This study aims to determine the mechanisms underlying restenosis and ischemia-reperfusion injury of the myocardium after percutaneous coronary intervention(PCI).Methods:The present study examined serial changes(5 min,30 min,2 h,6 h,and 24 h after PCI) in circulating P-selectin,plasminogen activator inhibitor-1(PAI-1),magnesium(Mg),and creatine kinase-myocardial band fraction(CK-MB) levels,which may be associated with restenosis and myocardial injury in patients undergoing PCI.The occurrence rates of major adverse cardiovascular events were collected over a six-month follow-up.Results:PCI induced an early elevation of P-selectin,which correlated positively with the inflation pressure used in the PCI procedure.PCI also caused a significant and sustained decrease in serum Mg in PCI patients,without an effect on PAI-1.An increase in CK-MB was observed in PCI patients,although values were within normal reference range.In addition,elevated P-selectin and decreased Mg measured shortly after the coronary angioplasty procedure were associated with recurrent treatment and heart failure,respectively.Conclusions:Our study demonstrates that PCI induces temporal changes of P-selectin,Mg,and CK-MB,which may be involved in restenosis and ischemia-reperfusion injury.These findings highlight the need for using antiplatelet therapy and Mg to reduce the risks associated with PCI.