Synthesis of Substituted Aziridine from (1S,2S)-2-Amino-1- (4-Nitrophenyl)- 1,3-Propanediol

被引：0
|
作者：
Yang Shao-rong1
2.College of Chemistry
机构：
来源：
Wuhan University Journal of Natural Sciences | 2000年 / 03期
关键词：
aziridines; synthesis; chloramphenicol;
D O I：
暂无
中图分类号：
O621.34 [];
学科分类号：
070303 ; 081704 ;
摘要：
S, 3R)-2-acetooxymethanyl-3-(P-nitrophenyl)-N-tosylaz iridine 5 was synthesized from (1S, 2S)-2-amino-1- (4-nitrophenyl)-1, 3-propaned iol 1 in four steps with a 24.8% overall yield. This reaction is ste reospecific and occ urs an expectable configuration inversion at α-carbon atom of benzyl group. Th e structure of substituted aziridine was determined on FT-IR, NMR, MS and so on .
引用
收藏
页码：345 / 347
页数：3
相关论文
共 50 条
  • [41] High-performance liquid chromatographic separation of unusual amino acid enantiomers derivatized with (1S,2S)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propyl-isothiocyanate
    Péter, A
    Péter, M
    Fülöp, F
    Török, G
    Tóth, G
    Tourwé, D
    Sápi, J
    CHROMATOGRAPHIA, 2000, 51 (1) : S148 - S154
  • [42] High-performance liquid chromatographic separation of unusual amino acid enantiomers derivatized with (1S,2S)-1,3-diacetoxy-1-(4-nitrophenyl)-2-propyl-isothiocyanate
    A. Péter
    M. Péter
    F. Fülöp
    G. Török
    G. Tóth
    D. Tourwé
    J. Sápi
    Chromatographia, 2000, 51 : S148 - S154
  • [43] ENANTIOSELECTIVE SYNTHESES OF (2S)-1-BENZYLOXY-2,3-PROPANEDIOL AND (2R)-1-AMINO-2,3-PROPANEDIOL FROM GLYCEROL
    HSU, CY
    LIN, YS
    UANG, BJ
    TETRAHEDRON-ASYMMETRY, 1990, 1 (04) : 219 - 220
  • [44] The ρ(1S, 2S), ψ(1S, 2S), Υ(1S, 2S) and ψt(1S, 2S) Mesons in a Double Pole QCD Sum Rule
    M. S. Maior de Sousa
    R. Rodrigues da Silva
    Brazilian Journal of Physics, 2016, 46 : 730 - 739
  • [45] (1R*,2S*)-2-Nitro-1-(4-nitrophenyl)-propanol
    Zhang, Xu
    Yang, Le
    Zhang, Jun-na
    He, Wei
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O881 - U3250
  • [46] A new selective oxidation of N-methyl to N-formyl upon threo-(1S,2S)2-(N, N-dimethylamino)-1-(4′-nitrophenyl)-1,3-propanediol
    Shan, ZX
    Lu, GJ
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2004, 24 (03) : 325 - 327
  • [47] The ρ(1S, 2S), ψ(1S, 2S), Iyen(1S, 2S) and ψ t (1S, 2S) Mesons in a Double Pole QCD Sum Rule
    Maior de Sousa, M. S.
    Rodrigues da Silva, R.
    BRAZILIAN JOURNAL OF PHYSICS, 2016, 46 (06) : 730 - 739
  • [48] A new and practical method for preparing enantiomerically pure [1,1′-binaphthalene]-2,2′-diol:: Resolution of racemic [1,1′-binaphthalene]-2,2′-diol with threo-(1S,2S)-2-amino-1-(4-nitrophenyl)propane-1,3-diol-cyclohexanone condensate
    Liu, DJ
    Shan, ZX
    Liu, F
    Xiao, C
    Lu, GJ
    Qin, JG
    HELVETICA CHIMICA ACTA, 2003, 86 (01) : 157 - 163
  • [49] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF CHLORAMPHENICOL AND 2-AMINO-1-(P-NITROPHENYL)-1,3-PROPANEDIOL IN PHARMACEUTICAL FORMULATIONS
    LEBELLE, MJ
    YOUNG, DC
    GRAHAM, KC
    WILSON, WL
    JOURNAL OF CHROMATOGRAPHY, 1979, 170 (01): : 282 - 287
  • [50] Regioselectivity in the reaction of paraformaldehyde with (1S,2S)-2-aryl(hetaryl)methylamino-1-(4-nitrophenyl)-13-propanediols
    Couquelet J.
    Madesclaire M.
    Leal F.
    Zaitsev V.P.
    Sharipova S.Kh.
    Chemistry of Heterocyclic Compounds, 1999, 35 (4) : 474 - 478
12345