Protective Effect of Shenfu Injection on Rats with Chronic Heart Failure Induced by Doxorubicin

被引：0

作者：

Qingli LI ^{[1
,2
]}

Guirong ZENG ^{[1
]}

Zhichao TAN ^{[1
]}

Xiaoqing WANG ^{[1
]}

Hongliang ZENG ^{[1
,3
]}

机构：

[1] Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs

[2] Hunan Fang Sheng Pharmaceutical Co.,Ltd. Postdoctoral Work Station

来源：

Medicinal Plant | 2018年 / 04期

关键词：

Shenfu injection; Doxorubicin; Chronic heart failure; Cardiac function parameters;

D O I：

10.19600/j.cnki.issn2152-3924.2018.04.031

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

[Objectives] To determine the protective effect of Shenfu injection( SFI) on chronic heart failure( CHF) in rats induced by doxorubicin. [Methods] CHF was induced by doxorubicin via intraperitoneal injection in rats. The cardiac function parameters,the heart index,the serum brain natriuretic peptide( BNP) level and cardiac histopathology were measured 4 weeks after Shenfu injection treatment. [Results]Shenfu injection remarkably improved the heart index and cardiac histopathology,increased the heart rate( HR),left ventricular systolic pressure( LVSP),maximum rising rate of left ventricular pressure( + dp/dtmax) and dropping rate of left ventricular pressure(-dp/dtmax),reduced the left ventricular end-diastolic pressure( LVEDP) and serum BNP level of rats with CHF induced by doxorubicin. [Conclusions]Shenfu injection exerts protective effect on CHF induced by doxorubicin.

引用

页码：110 / 113 +118

页数：5

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