Efficacy of nanofibrous conduits in repair of longsegment sciatic nerve defects

被引：0

作者：

Esmaeil Biazar ^{[1
]}

Saeed Heidari Keshel ^{[2
,3
]}

Majid Pouya ^{[4
]}

机构：

[1] Department of Biomaterial Engineering,Tonekabon Branch,Islamic Azad University,Tonekabon,Iran

[2] Student Research Committee,Proteomics Research Center,Faculty of Paramedical Sciences,Shahid Beheshti University of Medical Sciences,Tehran,Iran

[3] Department of Tissue Engineering,School of Advanced Technologies in Medicine,Tehran University of Medical Sciences,Tehran,Iran

[4] Faculty of Medical Sciences,Tonekabon Branch,Islamic Azad University,Tonekabon,Iran

来源：

Neural Regeneration Research | 2013年 / 8卷 / 27期

关键词：

neural regeneration; peripheral nerve injury; sciatic nerve; nerve conduit; poly(3-hydroxybutyrateco-3-hydroxyvalerate); behaviors; motor function; nociceptive function; grants-supported paper; neuroregeneration;

D O I：

暂无

中图分类号：

R651.3 [周围神经];

学科分类号：

1002 ; 100210 ;

摘要：

Our previous studies have histomorphologically confirmed that nanofibrous poly(3-hydroxybutyrateco-3-hydroxyvalerate) conduit can be used to repair 30-mm-long sciatic nerve defects.However,the repair effects on rat behaviors remain poorly understood.In this study,we used nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit and autologous sciatic nerve to bridge 30-mm-long rat sciatic nerve gaps.Within 4 months after surgery,rat sciatic nerve functional recovery was evaluated per month by behavioral analyses,including toe out angle,toe spread analysis,walking track analysis,extensor postural thrust,swimming test,open-field analysis and nociceptive function.Results showed that rat sciatic nerve functional recovery was similar after nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit and autologous nerve grafting.These findings suggest that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit is suitable in use for repair of long-segment sciatic nerve defects.

引用

页码：2501 / 2509

页数：9

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