12 polycythemia vera (PV) patients treated with iv drip harringtonine in 14 treatment courses all achieved complete remissions (CR) in a median 60 days. 4 relapsed, 2 of these retreated with harringtonine alone again achieved CR. The harringtonine median total dose is 98 mg. Follow up shows that harringtonine is a safe reliable new PV therapy, comparing favorably with the other PV treatments. It has not caused acute leukemia sequelae as some other anti-PV drugs.