Reduced glutathione alleviates the toxic effect of 6-hydroxydopamine on bone marrow stromal cells

被引：0

作者：

Henghui Wang Weifeng Luo Xiaoxia Wang Xiaoling Qin Shiyao Bao Department of Neurology the Second Affiliated Hospital of Soochow University Suzhou Jiangsu Province China Department of Oncology the Second Affiliated Hospital of Soochow University Suzhou Jiangsu Province China ^{[1
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机构：

来源：

NeuralRegenerationResearch | 2011年 / 6卷 / 22期

关键词：

reduced glutathione; 6-hydroxydopamine; bone marrow stromal cells; toxicity; Parkinson’s disease; neurodegenerative disease; neural regeneration;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

We studied the effect of reduced glutathione on bone marrow stromal cells (BMSCs) treated with 6-hydroxydopamine (6-OHDA), which shows a toxic effect on dopaminergic neurons. The proliferation of BMSCs treated with 6-OHDA decreased, while that of BMSCs treated with reduced glutathione increased. The proliferation of BMSCs treated with both 6-OHDA and reduced glutathione was significantly higher compared with that treated with 6-OHDA alone. These findings indicate that reduced glutathione alleviates the toxic effect of 6-OHDA on BMSCs.

引用

页码：1691 / 1695

页数：5

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