Association between MCP-1 gene polymorphism and acute coronary syndrome in a Han ethnic Chinese cohort

被引：0

作者：

Gan-wei Shi ^{[1
]}

Guo-ping He ^{[1
]}

Gao-jun Cai ^{[1
]}

Chuan-ping Qi ^{[2
]}

Lei Gao ^{[1
]}

Dan-dan Shen ^{[1
]}

Zhi-hong Qian ^{[1
]}

Lian-hong Xu ^{[2
]}

机构：

[1] Department of Cardiology,Affiliated Wujin Hospital of Jiangsu University

[2] Department of Central Laboratory,Affiliated Wujin Hospital of Jiangsu University

来源：

World Journal of Emergency Medicine | 2013年 / 01期

关键词：

Monocyte chemoattractant protein-1; Acute coronary syndrome; Polymorphism;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND:Acute coronary syndrome(ACS) is a multifactorial disease influenced by environmental and genetic factors.A growing number of human epidemiological studies have suggested that the chemokine,monocyte chemo-attractant protein-1(MCP-1) are involved in atherosclerosis and ACS,but genetic evidence is contradictory.We investigated the A-2518 G polymorphism of the MCP-1 gene in a Han Chinese cohort of patients with acute coronary heart disease.METHODS:The study comprised 484 patients and 346 healthy controls.This polymorphism was determined by using the polymerase chain reaction-restriction fragment length polymorphism method.RESULTS:Our data showed that frequency distribution of the genotype(AA:16.12%,AG:51.86%and GG:32.02%in cases;AA:15.32%,AG:53.47%and GG:31.21%in controls;P was0.762 and 0.914,respectively;) and G allele genotype(57.95%in cases;57.95%in controls;P was1.000) were not significantly different between the patients and controls.CONCLUSION:This study showed that there is no significant association between A-2518 G polymorphism of the MCP-1 gene and ACS in the Han Chinese population.

引用

页码：38 / 42

页数：5

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