Locus coeruleus-norepinephrine: basic functions and insights into Parkinson's disease

被引：2

作者：

Bilal Abdul Bari ^{[1
]}

Varun Chokshi ^{[1
]}

Katharina Schmidt ^{[2
]}

机构：

[1] The Solomon H. Snyder Department of Neuroscience, Brain Science Institute, Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine

[2] Department of Physiology, The Johns Hopkins University School of Medicine

来源：

Neural Regeneration Research | 2020年 / 15卷 / 06期

基金：

美国国家卫生研究院;

关键词：

catecholamines; copper; neurodegenerative diseases; neuromodulation; neuronal circuits; neuropsychiatric symptoms; noradrenaline; synaptic plasticity;

D O I：

暂无

中图分类号：

R742.5 [震颤麻痹综合征];

学科分类号：

1002 ;

摘要：

The locus coeruleus is a pontine nucleus that produces much of the brain’s norepinephrine.Despite its small size,the locus coeruleus is critical for a myriad of functions and is involved in many neurodegenerative and neuropsychiatric disorders.In this review,we discuss the physiology and anatomy of the locus coeruleus system and focus on norepinephrine’s role in synaptic plasticity.We highlight Parkinson’s disease as a disorder with motor and neuropsychiatric symptoms that may be understood as aberrations in the normal functions of locus coeruleus.

引用

页码：1006 / 1013

页数：8

共 47 条

[1]

Locus Coeruleus tracking of prediction errors optimises cognitive flexibility: An Active Inference model[J] . Anna C. Sales,Karl J. Friston,Matthew W. Jones,Anthony E. Pickering,Rosalyn J. Moran.PLOS Computational Biology . 2019 (1)

[2] Neuromelanin-sensitive magnetic resonance imaging features of the substantia nigra and locus coeruleus in de novo Parkinson's disease and its phenotypes [J].

Wang, J. ;

Li, Y. ;

Huang, Z. ;

Wan, W. ;

Zhang, Y. ;

Wang, C. ;

Cheng, X. ;

Ye, F. ;

Liu, K. ;

Fei, G. ;

Zeng, M. ;

Jin, L. .

EUROPEAN JOURNAL OF NEUROLOGY, 2018, 25 (07) :949-+

[3] Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context [J].

Wagatsuma, Akiko ;

Okuyama, Teruhiro ;

Sun, Chen ;

Smith, Lillian M. ;

Abe, Kuniya ;

Tonegawa, Susumu .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (02) :E310-E316

[4] Ancestral Circuits for the Coordinated Modulation of Brain State [J].

Lovett-Barron, Matthew ;

Andalman, Aaron S. ;

Allen, William E. ;

Vesuna, Sam ;

Kauvar, Isaac ;

Burns, Vanessa M. ;

Deisseroth, Karl .

CELL, 2017, 171 (06) :1411-+

[5]

Fear, Anxiety, and the Amygdala[J] . Pankaj Sah.Neuron . 2017 (1)

[6]

Role of the locus coeruleus catecholaminergic neurons in the chemosensory control of breathing in a Parkinson’s disease model[J] . Luiz M. Oliveira,Marina Tuppy,Thiago S. Moreira,Ana C. Takakura.Experimental Neurology . 2017

[7] Amyotrophic lateral sclerosis-like superoxide dismutase 1 proteinopathy is associated with neuronal loss in Parkinson's disease brain [J].

Trist, Benjamin G. ;

Davies, Katherine M. ;

Cottam, Veronica ;

Genoud, Sian ;

Ortega, Richard ;

Roudeau, Stephane ;

Carmona, Asuncion ;

De Silva, Kasun ;

Wasinger, Valerie ;

Lewis, Simon J. G. ;

Sachdev, Perminder ;

Smith, Bradley ;

Troakes, Claire ;

Vance, Caroline ;

Shaw, Christopher ;

Al-Sarraj, Safa ;

Ball, Helen J. ;

Halliday, Glenda M. ;

Hare, Dominic J. ;

Double, Kay L. .

ACTA NEUROPATHOLOGICA, 2017, 134 (01) :113-127

[8] Onset and evolution of anxiety in Parkinson's disease [J].

Zhu, K. ;

van Hilten, J. J. ;

Marinus, J. .

EUROPEAN JOURNAL OF NEUROLOGY, 2017, 24 (02) :404-411

[9] Sleep to Remember [J].

Sara, Susan J. .

JOURNAL OF NEUROSCIENCE, 2017, 37 (03) :457-463

[10] Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory [J].

Kempadoo, Kimberly A. ;

Mosharov, Eugene V. ;

Choi, Se Joon ;

Sulzer, David ;

Kandel, Eric R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (51) :14835-14840

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